摘要
Abstract
Objective:To investigate the efficacy of Moluodan+modified quadruple sequential therapy on Helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG)and the effect on inflammatory factor.Method:A total of 96 CAG patients who were treated in Jiujiang NO.1 People's Hospital from March 2021 to March 2024 were divided into observation group and control group by the random number table method,with 48 cases in each group.The control group was treated with modified quadruple sequential therapy,and the observation group was treated with Moluodan on the basis of the control group.The clinical efficacy after 14 days of treatment and Hp negative conversion rate after 1 month of treatment were recorded.The levels of inflammatory factors and serum indexes before and after treatment were counted.Adverse reactions during treatment were recorded.Result:The clinical efficacy of the observation group was better than that of the control group,the difference was statistically significant(P<0.05).After treatment,the serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C reactive protein(CRP)in the observation group were lower than those before treatment and those in the control group,the differences were statistically significant(P<0.05).The levels of pepsinogen Ⅰ(PGⅠ),gastrin(GAS)in the observation group were higher than those before treatment and those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the level of pepsinogen Ⅱ(PGⅡ)between the two groups(P>0.05).One month after treatment,38 cases of Hp in the observation group turned negative,with a negative conversion rate of 79.17%;a total of 29 cases in the control group were Hp negative,and the negative conversion rate was 60.42%,the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Moluodan combined with modified quadruple sequential therapy is effective in the treatment of Hp-positive CAG,which can reduce the secretion of inflammatory cytokines and increase the Hp negative conversion rate of patients with high safety.关键词
改良四联序贯疗法/摩罗丹/炎症因子/幽门螺杆菌Key words
Modified quadruple sequential therapy/Moluodan/Inflammatory cytokines/Helicobacter pylori
