摘要
Abstract
Objective:To investigate the therapeutic effect of Acetylcysteine atomization combined with Moxifloxacin in patients with severe pneumonia.Method:A total of 80 patients with severe pneumonia admitted to Shangrao Central Hospital from January 2021 to January 2024 were selected by convenience sampling method and divided into two groups with 40 cases each according to random number table method.All patients were treated with conventional treatment.The control group was treated with Moxifloxacin,and the observation group was treated with Acetylcysteine atomization on the basis of the control group.Two groups were treated for 2 weeks.The therapeutic effect,serum inflammatory factors,blood gas analysis index,oxygenation index,symptom improvement and safety of the two groups were compared.Result:The total effective rate of the observation group was 95.00%,which was higher than 80.00%of the control group(P<0.05).After treatment,the C reactive protein(CRP)was(10.35±1.38)mg/L,the white blood cell(WBC)count was(9.51±1.10)×109/L,the procalcitonin(PCT)was(0.30±0.16)ng/mL,the arterial partial pressure of carbon dioxide(PaCO2)was(41.57±3.65)mmHg of the observation group,which were lower than(13.04±1.48)mg/L,(11.37±1.25)×109/L,(0.72±0.25)ng/mL,(46.74±3.26)mmHg of control group;arterial partial oxygen pressure(PaO2)was(78.51±4.01)mmHg,blood oxygen saturation(SaO2)was(95.56±1.37)%,oxygenation index(OI)was(170.57±15.30)mmHg of the observation group,which were higher than(72.67±4.45)mmHg,(93.04±1.29)%,(152.47±14.32)mmHg of the control group;fever improvement time was(4.27±0.34)d,cough improvement time was(5.06±0.88)d,lung rale improvement time was(5.42±0.81)d,lung shadow improvement time was(6.77±1.02)d in the observation group,which were shorter than(5.16±0.62),(6.12±0.97),(6.64±0.73),(8.86±1.14)d in the control group,the differences were statistically significant(P<0.05).No adverse reactions occurred in the two groups.Conclusion:Acetylcysteine atomization combined with Moxifloxacin can enhance the treatment effect of severe pneumonia,reduce the level of inflammation,improve the oxygenation index and blood gas analysis index,promote the regression of symptoms,and is safe and reliable.关键词
重症肺炎/乙酰半胱氨酸/莫西沙星/血清炎症因子/氧合指数Key words
Severe pneumonia/Acetylcysteine/Moxifloxacin/Serum inflammatory factor/Oxygenation index
