中国医学创新2025，Vol.22Issue(12)：144-148,5.DOI:10.3969/j.issn.1674-4985.2025.12.035
NLR、PLR、RDW联合IL-6在AECOPD预后不良中的意义及其预测效能分析
Significance of NLR,PLR,RDW Combined with IL-6 in Poor Prognosis of AECOPD and Its Predictive Efficacy Analysis
摘要
Abstract
Objective:To analyze the predictive value of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),red cell volume distribution width(RDW)combined with interleukin-6(IL-6)in poor prognosis of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Method:A total of 50 patients with AECOPD treated in the First People's Hospital of Fuzhou from June 2022 to June 2024 were selected as the study objects.The venous blood samples of all patients were collected,the levels of neutrophil,lymphocyte,platelet,RDW and IL-6 were detected,NLR and PLR were calculated,and the predictive value of NLR,PLR,RDW combined with IL-6 in the poor prognosis of AECOPD were analyzed.Result:Among the 50 patients with AECOPD,39 survived,with a survival rate of 78.00%.Compared with the death group,the levels of NLR,PLR,RDW,IL-6 and proportion of smoking history in the survival group were lower,and the age was young,the differences were statistically significant(P<0.05).logistic regression analysis showed that NLR,PLR,RDW,IL-6,age and smoking history were all influencing factors for the poor prognosis of AECOPD(P<0.05).The area under the curve(AUC)of NLR,PLR,RDW and IL-6 in predicting poor prognosis of AECOPD were 0.660,0.765,0.618 and 0.697,respectively.The AUC,sensitivity and specificity of the combination of NLR,PLR,RDW and IL-6 in predicting the poor prognosis of AECOPD were 0.810,81.56%and 84.24%,respectively.Conclusion:NLR,PLR,RDW,IL-6,age and smoking history are all influencing factors for the poor prognosis of AECOPD,and NLR,PLR,RDW combined with IL-6 has high efficacy in predicting the poor prognosis of AECOPD.关键词
中性粒细胞/淋巴细胞比值/血小板/淋巴细胞比值/红细胞体积分布宽度/白介素-6/慢性阻塞性肺疾病急性加重期/预后不良Key words
Neutrophil-to-lymphocyte ratio/Platelet-to-lymphocyte ratio/Red cell volume distribution width/Interleukin-6/Acute exacerbation of chronic obstructive pulmonary disease/Poor prognosis引用本文复制引用
陈招娣,游建华,谢文琦..NLR、PLR、RDW联合IL-6在AECOPD预后不良中的意义及其预测效能分析[J].中国医学创新,2025,22(12):144-148,5.基金项目
抚州市社会发展指导性科技计划项目(抚科社字[2024]1号第8项) （抚科社字[2024]1号第8项）
