中国医学装备2025，Vol.22Issue(4)：43-47,5.DOI:10.3969/j.issn.1672-8270.2025.04.009
视频脑电图联合C反应蛋白和降钙素原对伴惊厥发作中枢神经系统感染性疾病的诊断价值研究
Diagnostic value of video-electroencephalography combined with CRP and PCT in infectious diseases of the central nervous system with convulsions
摘要
Abstract
Objective:To analyze the diagnostic value of video-electroencephalography(VEEG)combined with C-reactive protein(CRP)and procalcitonin(PCT)in infectious diseases of the central nervous system with convulsions.Methods:This study included 100 pediatric patients with convulsions who were suspected as central nervous system infection at Bengbu First People's Hospital from May 2022 to May 2024.VEEG and laboratory tests were performed on them.These patients were divided into the infection group(36 cases)and the non-infection group(64 cases)according to whether they were judged as central nervous system infection by using testing cerebrospinal fluid.The abnormal situation of VEEG test,CRP and PCT levels of two groups were compared,and the consistency between the diagnostic result of VEEG combined with CRP and PCT,and the tested result of cerebrospinal fluid was further analyzed.The receiver operating characteristic(ROC)curve was adopted to analyze the diagnostic efficiency of VEEG combined with CRP and PCT.Results:In 36 pediatric patients of infection group,2 cases(5.56%)were within normal range of VEEG examination,and 11 cases(30.56%)were at cutoffvalue,and 23 cases(63.89%)were abnormal.In 64 pediatric patients of non-infection group,54 cases(84.38%)were normal,and 6 cases(9.38%)were within normal range,and 3 cases(4.68%)were at cutoffvalue,and 1cases(1.56%)were abnormal.The abnormal results of the infection group were significantly higher than those of the non-infection group(Z=8.81,P＜0.05).The CRP and PCT levels of infection group were significantly higher than those of non-infection group(t=6.859,5.410,P＜0.05).There was higher consistency between the diagnosis of VEEG combined with CRP and PCT,and the tested result of cerebrospinal fluid(Kappa=0.867).The ROC analysis showed that the AUC value,sensitivity and specificity of VEEG combined with CRP and PCT in diagnosing the central nervous system infection with convulsions were respectively 0.963,86.11%and 98.44%,which were higher than those of the single VEEG diagnosis.Conclusion:There are significant differences in VEEG abnormalities,CRP and PCT levels between pediatric patients with central nervous system infection with convulsions,and pediatric patients without central nervous system infection with convulsions.The diagnosis of applying VEEG combined with CRP and PCT has higher diagnostic efficiency in clinical work.关键词
视频脑电图(VEEG)/C反应蛋白(CRP)/降钙素原(PCT)/惊厥/中枢神经系统感染Key words
Video-electroencephalography(VEEG)/C-reactive protein(CRP)/Procalcitonin(PCT)/Convulsion/Central nervous system infection分类
医药卫生引用本文复制引用
张海燕,吴莉莉,尹远远,张颖..视频脑电图联合C反应蛋白和降钙素原对伴惊厥发作中枢神经系统感染性疾病的诊断价值研究[J].中国医学装备,2025,22(4):43-47,5.基金项目
安徽省卫生健康科研项目(AHWS2022b112) Anhui Provincial Health Research Project(AHWS2022b112) （AHWS2022b112）
