中国药业2025，Vol.34Issue(8)：46-50,5.DOI:10.3969/j.issn.1006-4931.2025.08.011
单核苷酸多态性对原发性中枢神经系统淋巴瘤患者甲氨蝶呤疗效的影响
Effect of Single Nucleotide Polymorphism on the Efficacy of Methotrexate in Patients with Primary Central Nervous System Lymphoma
摘要
Abstract
Objective To investigate the effect of single nucleotide polymorphisms(SNPs)of 13 loci of 6 genes SLCO1B1,SLC19A1,ABCC2,ABCB1,FPGS and GGH on the efficacy of four cycles of MTX chemotherapy in patients with primary central nervous system lymphoma(PCNSL).Methods Patients who were newly diagnosed with PCNSL and evaluated by four cycles of efficacy in Huashan Hospital,Fudan University were selected as the research subjects from January 2017 to July 2021,and the general data,disease treatment data and laboratory test results were collected.The demographic data and clinical data of 86 patients with PCNSL were obtained from the clinical electronic medical record system.The patient's DNA samples were typed by matrix-assisted laser desorption ionization time of flight mass spectrometry.The effect of SNPs on the efficacy of MTX was analyzed by χ2 test and multivariate Logistic regression.Results Univariate analysis showed that the SNPs of rs1045642,rs2032582 and rs2305558 had an effect on the efficacy of MTX in patients with PCNSL(P<0.05).Multiple regression analysis showed that rs1045642 still had an effect on the efficacy of MTX(P<0.05)after including confounding factors such as total dose of MTX,gender,age,height.Conclusion ABCB1 rs1045642 genotype can be used as an independent influencing factor of MTX efficacy.This study provides a basis for clinical individualized dosing of MTX.关键词
甲氨蝶呤/原发性中枢神经系统淋巴瘤/单核苷酸多态性/个体化给药Key words
methotrexate/primary central nervous system lymphoma/single nucleotide polymorphisms/individualized dosing分类
药学引用本文复制引用
武卓,吴晗,邱晓燕,王斌,丁天凌..单核苷酸多态性对原发性中枢神经系统淋巴瘤患者甲氨蝶呤疗效的影响[J].中国药业,2025,34(8):46-50,5.基金项目
国家自然科学基金[82003863] （）
上海市卫生健康委员会科研课题[201740058,202040424] （）
上海市"医苑新星"青年医学人才培养资助计划项目[沪卫人事[2021]99号]. （）
