中国药业2025，Vol.34Issue(8)：64-67,4.DOI:10.3969/j.issn.1006-4931.2025.08.015
长春地区2型糖尿病伴脂代谢异常患者ApoE及SLCO1B1基因多态性研究
Study on ApoE and SLCO1B1 Gene Polymorphisms in Patients with Type 2 Diabetes Mellitus with Abnormal Lipid Metabolism in Changchun Area
摘要
Abstract
Objective To investigate the gene polymorphisms distribution of ApoE and SLCO1B1 in type 2 diabetes mellitus(T2DM)patients with abnormal lipid metabolism in Changchun area.Methods A total of 300 patients admitted to the hospital were selected.The ApoE gene loci[c.526C>T(rs429358)and c.388T>C(rs7412)]and SLCO1B1 gene loci[c.521 T>C(rs4149056)and c.388 A>G(rs2306283)]in peripheral blood were detected by in situ hybridization,and the characteristics of gene polymorphism distribution were analyzed.The genotype distribution among different genders and different regions were compared,and the differences in the levels of glycosylated hemoglobin(HbA1C)of various type between the two genes.Results All six ApoE genotypes were detected,including E2/E2(0.33%),E2/E3(12.33%),E2/E4(0.67%),E3/E3(67.67%),E3/E4(16.67%),and E4/E4(2.33%).The general population of genotype(E2/E4,E3/E3)was highest(68.33%).Seven of the nine SLCO1B1 genotypes(except *1a/*5 and *5/*5)were detected,and the normal disease risk proportion of genotypes(*1a/*1a,*1a/*1b,*1b/*1b)was highest(77.00%).The gene polymorphism frequency distribution of the two genes satisfied the Hardy-Weinberg genetic balance and was representative of the population.There was no significant difference in the distribution of genotype combinations between different genders(P>0.05).There was no significant difference in the distribution of ApoE and SLCO1B1 genotypes between Changchun area and the area of Central China,South China and Beijing(P>0.05),and there was no significant difference in HbA1C levels among the various ApoE and SLCO1B1 genotypes in Changchun area(P>0.05).Conclusion The ApoE and SLCO1B1 genotypes of T2DM patients with abnormal lipid metabolism in Changchun area were mainly the general population genotype with normal statin efficacy and the normal disease risk proportion genotypes with high dose tolerance of statins.Taking statins has a lower risk of inducing myopathy and a better lipid-lowering effect,and the characteristics of gene polymorphisms distribution in the two genes were not affected by gender.The detection of polymorphisms in two genes can assist in the clinical formulation of individualized dosage regimen of statins and reduce the occurrence of adverse reactions.关键词
ApoE/SLCO1B1/基因多态性/2型糖尿病/脂代谢异常/长春地区Key words
ApoE/SLCO1B1/gene polymorphisms/type 2 diabetes/abnormal lipid metabolism/Changchun area分类
医药卫生引用本文复制引用
宁鑫,张连波,李清波,孙婷婷..长春地区2型糖尿病伴脂代谢异常患者ApoE及SLCO1B1基因多态性研究[J].中国药业,2025,34(8):64-67,4.基金项目
吉林省卫生健康科技能力提升项目[2021LC098]. （）
