中国药业2025，Vol.34Issue(8)：91-93,3.DOI:10.3969/j.issn.1006-4931.2025.08.021
司库奇尤单抗联合卡泊三醇软膏治疗中重度斑块状银屑病临床观察
Clinical Observation of Botriol Ointment Combined with Sikuximab Injection in the Treatment of Moderate to Severe Plaque Psoriasis
摘要
Abstract
Objective To investigate the clinical efficacy of secukinumab combined with calcipotriol ointment in the treatment of moderate to severe plaque psoriasis.Methods A total of 118 patients with moderate to severe plaque psoriasis admitted to the hospital from September 2022 to September 2023 were selected.They were divided into a control group and an observation group according to the random number table method,with 59 patients in each group.Both groups were applied with calcipotriol ointment,and the observation group was additionally given subcutaneous injection of Secukinumab Injection.Both groups were treated continuously for 12 weeks.Results Compared with those before treatment,the Psoriasis Area and Severity Index(PASI)scores and Dermatology Life Quality Index(DLQI)scores of the patients in both groups were significantly decreased after treatment(P<0.05),and the scores of Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)were also significantly decreased(P<0.05).The sebum content and the water content of the stratum corneum were significantly increased(P<0.05),and the improvement of the above indicators in the observation group was more significant(P<0.05).The incidence of adverse reactions in the observation group was 5.08%,which was significantly lower than 16.95%in the control group(P<0.05).Conclusion Calcipotriol ointment combined with secukinumab injection in the treatment of moderate to severe plaque psoriasis can reduce the severity of skin lesions in patients,improve their quality of life,and ameliorate their adverse psychological emotions and skin barrier function.关键词
中重度/斑块状银屑病/司库奇尤单抗注射液/卡泊三醇软膏/生活质量/负性情绪Key words
moderate to severe/psoriasis/Secukinumab Injection/calcipotriol ointment/quality of life/negative emotion分类
医药卫生引用本文复制引用
马涛,陆延娜,徐亚楠..司库奇尤单抗联合卡泊三醇软膏治疗中重度斑块状银屑病临床观察[J].中国药业,2025,34(8):91-93,3.基金项目
陕西省延安市科学技术研究发展计划项目[2018KS-27]. （）
