针灸临床杂志2025，Vol.41Issue(4)：6-12,7.DOI:10.19917/j.cnki.1005-0779.025063
外泌体参与骨性关节炎发病过程的作用机制及针刺调节作用
The Role of Exosomes in the Pathogenesis of Osteoarthritis and the Regulatory Effects of Acupuncture
摘要
Abstract
Acupuncture therapy has been widely applied in the treatment of osteoarthritis(OA).Studies have shown that acupuncture primarily alleviates OA pathology by improving the local microenvironment,regulating inflammatory response,and modulating the immune and nervous systems.However,the precise therapeutic mechanisms of acupuncture remain unclear and require further investigation.Exosomes,as small extracellular vesicles released by cells,play a crucial role in cellular communication and functional regulation.Acupuncture has been found to influence exosomes release,and preliminary studies suggest that exosomes and the released substances may amplify acupuncture signals in a cascade-like manner.This study explores the role of exosomes in the pathogenesis of OA and the regulatory effect of acupuncture,providing a theoretical basis for exploring the deeper mechanisms of acupuncture in the treatment of OA.关键词
骨性关节炎/外泌体/针刺Key words
Osteoarthritis/Exosomes/Acupuncture分类
中医学引用本文复制引用
丁静,郑洁..外泌体参与骨性关节炎发病过程的作用机制及针刺调节作用[J].针灸临床杂志,2025,41(4):6-12,7.基金项目
国家自然科学基金,编号:82374265 （）
陕西省科技厅项目,编号:2022SF-184. （）
