慢性应激促进肿瘤进展和转移的机制及其治疗现状
Chronic Stress Promotes Tumor Progression and Metastasis:From Mechanisms to Therapeutic Strategies
摘要
Abstract
Metastasis is a key cause of death in tumor patients,and a number of tumor patients have comorbid psychosomatic abnormalities and are in a state of chronic stress.Chronic stress affects the release of many kinds of hormones and neurotransmitters,such as epinephrine,norepinephrine,dopamine,glucocorticoids,cortisol,sex hormones,etc.,through the hypothalamus-pituitary-adrenal axis and sympathetic nervous system.These substances can act on the β-adrenergic receptor,glucocorticoid receptor,etc.,on tumor cells,immune cells,and other cells in the tumor microenvironment and promote the tumor progression and metastasis by directly enhancing the invasive and metastatic ability of tumor cells,inducing the formation of the immunosuppressive microenvironment and promoting tumor angiogenesis and other pathways.Antip-sychotic drugs,β-blockers,and glucocorticoid receptor antagonists have inhibitory effects on chronic stress-mediated tumor metastasis and have achieved certain clinical efficacy.Relevant studies have been carried out on traditional Chinese medicine decoctions and monomers,which can inhibit tumor metastasis by modulating the immune microenvironment and reversing chronic stress-mediated hormonal changes.The psychological problems of tumor patients have gradually received attention,and the development of new anti-metastatic drugs based on the mechanism of action of chronic stress in promoting tumor progression and metastasis provides new ideas for the improvement of the overall efficiency of tumor prevention and treatment.关键词
肿瘤/转移/慢性应激/免疫/β-肾上腺素能受体/糖皮质激素受体/治疗现状Key words
Tumor/Metastasis/Chronic stress/Immune/β-adrenergic receptor/Glucocorticoid receptor/Therapeutic status分类
医药卫生引用本文复制引用
于盼,姚嘉良,田建辉..慢性应激促进肿瘤进展和转移的机制及其治疗现状[J].肿瘤防治研究,2025,52(4):324-330,7.基金项目
National Natural Science Foundation of China(No.82305069) （No.82305069）
Shanghai Municipal Health Commission Leading Talent Program(No.2022LJ014) （No.2022LJ014）
Shanghai Shenkang Hospital Development Center's Second Round of Training Program for Research Physicians'Innovation and Translation Ability(No.SHDC2023CRD01) （No.SHDC2023CRD01）
Science and Technology Development Program of Shanghai University of Traditional Chinese Medicine in 2023(No.23KFL096) （No.23KFL096）
Shanghai Institute of Traditional Chinese Medicine and Psychosomatic Diseases 2023 Open Research Project(No.SZB2023102) （No.SZB2023102）
Future Plan for Traditional Chinese Medicine Development of Science and Technology of Shanghai Municipal Hospital of Traditional Chinese Medicine(No.WL-HBRC-2021001K) 国家自然科学基金(82305069) （No.WL-HBRC-2021001K）
上海市卫健委领军人才项目(2022LJ014) （2022LJ014）
上海申康医院发展中心第二轮研究型医师创新转化能力培训项目(SHDC-2023CRD01) （SHDC-2023CRD01）
2023年度上海中医药大学科技发展项目(23KFL096) （23KFL096）
上海市中医神志病研究所2023年度开放科研项目(SZB2023102) （SZB2023102）
上海市中医医院未来计划科技发展项目(WL-HBRC-2021001K) （WL-HBRC-2021001K）
