摘要
Abstract
Objective:To observe the clinical effect of low-frequency repetitive transcranial magnetic stimulation(LF-rTMS)in motor area combined with Fluoxetine Hydrochloride in patients with obsessive-compulsive disorder.Method:The clinical data of 100 patients with obsessive-compulsive disorder who admitted to Beijing Daxing District Xinkang Hospital from June 2022 to June 2023 were retrospectively analyzed,they were divided into the drug group(drug treatment,n=40)and the combined group(drug treatment combined with LF-rTMS treatment,n=60)according to different treatment methods.The clinical efficacy,obsessive-compulsive symptoms[Yale-Brown obsessive compulsive scale(Y-BOCS)],anxiety and depression symptoms[Hamilton depression scale(HAMD),Hamilton anxiety scale(HAMA)],quality of life[the MOS item short form health survey(SF-36)]and safety were compared between two groups.Result:The clinical total effective rate of the combined group was higher than that of the drug group,the difference was statistically significant(P<0.05);After 1 month of treatment and after treatment,the Y-BOCS scores of two groups were lower than those before treatment,and the Y-BOCS score after treatment in the combined group were lower than those in the drug group,the differences were statistically significant(P<0.05);after treatment,the HAMD scores and HAMA scores of two groups were lower than those before treatment,and those in the combined group were lower than those in the drug group,the differences were statistically significant(P<0.05);after treatment,the scores of physiological function(PF),social function(SF),emotional function(RE)and general health(GH)in two groups were higher than those before treatment,and those in the combined group were higher than those in the drug group,the differences were statistically significant(P<0.05);there were no significant differences in the incidence of adverse reactions between two groups(P>0.05).Conclusion:LF-rTMS combined with Fluoxetine Hydrochloride in the treatment of patients with obsessive-compulsive disorder can effectively improve the clinical effect,improve the symptoms of obsessive-compulsive,anxiety and depression,improve the quality of life,and has good safety.关键词
强迫障碍/运动区低频重复经颅磁刺激/盐酸氟西汀/临床疗效/安全性Key words
Obsessive-compulsive disorder/Low-frequency repetitive transcranial magnetic stimulation in motor area/Fluoxetine Hydrochloride/Clinical efficacy/Safety
