中医药学报2025，Vol.53Issue(4)：43-48,6.DOI:10.19664/j.cnki.1002-2392.250072
麦粒灸四花穴联合揿针治疗肝气郁结型抑郁症的临床研究
Clinical Study on Wheat-grain size cone moxibustion at Sihua Acupoints Combined with Thumbtack Needle for the Treatment of Depression with Liver Qi Stagnation Pattern
摘要
Abstract
Objective:To investigate the clinical efficacy of Wheat-Grain Size Cone Moxibustion at Sihua acupoints combined with thumbtack needling in treating depression with liver qi stagnation pattern.Methods:A total of 83 patients with depression treated at Foshan Hospital of Traditional Chinese Medicine from June 2022 to June 2023 were selected and randomly divided into two groups using a random number table.The control group(42 cases,2 dropped out,40 finally included)received conventional Western medicine treatment,while the study group(41 cases,1 dropped out,40 finally included)received the same plus wheat-grain size cone moxibustion at Sihua acupoints combined with thumbtack needling based on the control group's treatment.Clinical efficacy was compared after 4 weeks of treatment.Before and after treatment,patients were assessed using the Beck Depression Inventory-II(BDI-II),9-item Patient Health Questionnaire Depression Scale(PHQ-9),and Simplified Coping Style Questionnaire(SCSQ).Microarousal index,total sleep time,and sleep efficiency were measured.Levels of macrophage migration inhibitory factor(MIF),γ-aminobutyric acid(GABA),5-hydroxytryptamine(5-HT),tumor necrosis factor-α(TNF-α),CC chemokine ligand 2(CCL2),homovanillic acid(HVA),and 3-methoxy-4-hydroxyphenylglycol(MHPG)were detected.Results:The total effective rate was 97.50%(39/40)in the study group and 80.00%(32/40)in the control group.The study group showed a higher total effective rate than the control group(P<0.05).BDI-II and PHQ-9 scores in the study group were lower than those in the control group(P<0.01),while the SCSQ score was higher(P<0.01).The study group had fewer microarousals(P<0.01),higher sleep efficiency(P<0.01),and longer total sleep time(P<0.01)compared to the control group.The combined moxibustion and thumbtack needling group showed significantly lower levels of MIF,TNF-α,and CCL2 than the control group(P<0.01).Levels of GABA,5-HT,HVA,and MHPG in the study group were higher than those in the control group(P<0.01).Conclusion:Wheat-grain size cone moxibustion at Sihua acupoints combined with thumbtack needling can reduce inflammatory damage,improve neurotransmitter levels,alleviate depressive symptoms,enhance sleep quality and coping strategies,and increase clinical efficacy in patients with depression of liver qi stagnation pattern.关键词
麦粒灸四花穴/揿针/肝气郁结型抑郁症/炎症损伤/神经递质/睡眠质量Key words
Wheat-grain size cone moxibustion at Sihua acupoints/Thumbtack needling/Depression with liver qi stagnation pattern/Inflammatory damage/Neurotransmitter/Sleep quality分类
中医学引用本文复制引用
陈哲子,伍秋月,刘玉莲..麦粒灸四花穴联合揿针治疗肝气郁结型抑郁症的临床研究[J].中医药学报,2025,53(4):43-48,6.基金项目
广东省卫生健康委科研基金(GDYYB21058) （GDYYB21058）
