中医药信息2025，Vol.42Issue(4)：29-33,5.DOI:10.19656/j.cnki.1002-2406.20250405
针刺介导HCN通道调节胃肠道ENS-ICC-SMC功能网络的机制探析
Mechanism of Acupuncture-Mediated HCN Channel Regulating Gastrointestinal ENS-ICC-SMC Functional Network
摘要
Abstract
The disorders of gastrointestinal motility(DGIM)are common diseases in clinical practice,and acupuncture has been shown to be effective in treating these conditions.hyperpolarization activated cyclic nucleotide gated channels(HCN),which play a key role in neuro-signaling and the formation of action potentials in cells,is crucial for the regulation of gastrointestinal motility.The Enteric Nervous System(ENS)-Interstitial Cells of Cajal(ICC)-Smooth Muscle Cells(SMC)functional network is the fundamental functional unit of gastrointestinal motility and a critical link in the regulation of gastrointestinal motility.However,there is insufficient research evidence regarding whether the HCN channel is involved in acupuncture's regulation of the gastrointestinal ENS-ICC-SMC functional network.Therefore,this article focuses on the gastrointestinal ENS-ICC-SMC functional network as a target and explores the possible mechanisms of acupuncture regulation of gastrointestinal motility via HCN.It was found that HCNs,which play an essential role in cell excitability,rhythmicity,and neuro-signaling,are widely expressed in the gastrointestinal tract and can regulate the function of ENS,ICC,and SMC by affecting cellular morphology,structure,and physiological function,thus impacting the ENS-ICC-SMC functional network.Current research has demonstrated that acupuncture can affect individual components within the ENS-ICC-SMC network,mainly focusing on the ICC-related section,by regulating the expression level and function of HCNs.However,there is still insufficient research on the ENS,SMC,and the entire functional network.关键词
胃肠动力障碍性疾病/针刺/胃肠动力/HCN通道/ENS-ICC-SMC功能网络Key words
Gastrointestinal motility disorders/Acupuncture/Gastrointestinal motility/HCNs/ENS-ICC-SMC functional network引用本文复制引用
李雨宜,杨钰涛,柳熠玲,邓芙蓉,朱姝静,黄永思,钟峰..针刺介导HCN通道调节胃肠道ENS-ICC-SMC功能网络的机制探析[J].中医药信息,2025,42(4):29-33,5.基金项目
国家自然科学基金项目(82374595) （82374595）
湖南省自然科学基金项目(2021JJ30530) （2021JJ30530）
湖南省研究生科研创新项目(2023CX44) （2023CX44）
