北京中医药大学学报2025，Vol.48Issue(4)：559-565,7.DOI:10.3969/j.issn.1006-2157.2025.04.014
基于伏毒阻络辨治阿尔茨海默病源性轻度认知障碍的思路探究
Exploring the idea of differentiating and treating mild cognitive impairment due to Alzheimer's disease based on latent toxin blocking collaterals
摘要
Abstract
Mild cognitive impairment due to Alzheimer's disease is an inevitable pathological stage in the early development of Alzheimer's disease,which can be classified as"microlumps in the brain collaterals"in traditional Chinese medicine.Based on the theory of latent toxin blocking collaterals,this article discusses the etiology and pathogenesis,clinical sequelae,and traditional Chinese medicine intervention strategies for mild cognitive impairment due to Alzheimer's disease.The onset of mild cognitive impairment due to Alzheimer's disease is very similar to the latent pathogen theory,which states that"the latent pathogen is latent and then develops,the poison is deep and difficult to cure,and the development can be recognized but the latent pathogen cannot be detected."Combining clinical experience,our team believes that the basic nature of the disease is a slight deficiency and a slight excess of symptoms.A slight deficiency of the five zang viscera and six fu viscera as root and a latent toxin colling collaterals of qi,fire,phlegm,and blood stasis as manifestaion.These usually start from the qi depression and develop into phlegm coagulation and blood stasis,then end up in latent toxin and gradually become the healthy qi deficiency.Therefore,the deficiency of vital qi and incubation of evil,latent toxin blocking collaterals the pathogenesis of early intervention of this disease should be carried out,upholding the idea that"the upper workman treats the disease before it is diagnosed."The principle of strengthening vital qi to eliminate pathogenic factors,slowing down and promoting pathogenic factors elimination,establishing the method of supporting correctness and wisdom,simultaneously detoxifying and clearing the blood stasis,pattern differentiation as the main and the disease differentiation as the first,combining the disease and pattern,and adjusting the macroscopic and microscopic,focusing simultaneously on eliminating and replenishing,dispel phlegm and remove blood stasis,achieve a strong vital qi and the elimination of evil,and enhance intelligence,delay or even block the progression of mild cognitive impairment due to Alzheimer's disease,improve patients' quality of life,and provide a theoretical basis for the early clinical prevention and treatment of Alzheimer's disease.关键词
伏毒阻络/阿尔茨海默病源性轻度认知障碍/脑络微癥积/病因/病机/中医辨治Key words
latent toxin blocking collaterals/mild cognitive impairment due to Alzheimer's disease/micro-lumps in the brain/etiology/pathogenesis/traditional Chinese medicine treatment based on disease differentiation分类
医药卫生引用本文复制引用
席虎,杨文明,李浩,谢文婷,杨悦,翟舒..基于伏毒阻络辨治阿尔茨海默病源性轻度认知障碍的思路探究[J].北京中医药大学学报,2025,48(4):559-565,7.基金项目
国家科技重大专项(No.2023ZD0505801) （No.2023ZD0505801）
安徽省自然科学基金青年项目(No.2108085QH368) （No.2108085QH368）
安徽省卫生健康科研项目(No.AHWJ2022b086) （No.AHWJ2022b086）
合肥综合性国家科学中心大健康研究院新安医学与中医药现代化研究所"揭榜挂帅"项目(No.2024CXMMTCM001) National Science and Technology Major Project(No.2023ZD0505801) （No.2024CXMMTCM001）
