北京中医药大学学报2025，Vol.48Issue(4)：566-572,7.DOI:10.3969/j.issn.1006-2157.2025.04.015
基于"火与元气不两立"探讨运用甘药治疗肿瘤免疫相关不良反应
Discussion on the application of sweet-natured herbs to the treatment of tumor immune-related adverse events based on the theory of"fire and primordial qi incompatibility"
摘要
Abstract
The theory of"fire and primordial qi incompatibility"was proposed by LI Gao in Clarifying Doubts about Damage from Internal and External Causes,which has important guiding significance for explaining the pathogenesis,prognosis and treatment of immune-related adverse events(irAEs)."Fire"refers to yin fire,a type of deficient fire transformed from the deficiency of the spleen and stomach,reflecting the pathological state of coexisting deficiency and heat patterns in patients with tumor after immune checkpoint inhibitor(ICI)therapy."Primordial qi"is the most fundamental essence of human life activities and serves as the source of all bodily qi.Based on the theory of"fire and primordial qi incompatibility"and Western medicine research,we found that excessive use of ICIs can damage the spleen and stomach,leading to excessive yin fire.When yin fire becomes excessive,it consumes and injures the primordial qi;when the primordial qi is depleted,it leads to more excessive yin fire and further deficiency of the spleen and stomach,forming a syndrome in which deficiency and excess coexist.Starting from the theory of"fire and primordial qi incompatibility,"combined with our team's clinical practice and modern pharmacological research,this study explores the application characteristics of sweet-natured herbs for irAEs during ICIs therapy and interval periods,and summarizes the treatment principles,aiming to provide new perspectives and approaches for the prevention and treatment of tumor-related irAEs with traditional Chinese medicine.关键词
火与元气不两立/免疫相关不良反应/甘药/肿瘤治疗/免疫检查点抑制剂Key words
fire and primordial qi incompatibility/immune-related adverse events/sweet-natured herbs/tumor therapy/immune checkpoint inhibitors分类
医药卫生引用本文复制引用
吴佳禾,崔慕瑶,李卫东..基于"火与元气不两立"探讨运用甘药治疗肿瘤免疫相关不良反应[J].北京中医药大学学报,2025,48(4):566-572,7.基金项目
国家自然科学基金面上项目(No.82174464) （No.82174464）
中央高水平中医医院临床研究和成果转化能力提升项目(No.HLCMHPP2023085) （No.HLCMHPP2023085）
中国中医科学院科技创新工程(No.CI2021A01806) National Natural Science Foundation of China(No.82174464) （No.CI2021A01806）
