川北医学院学报2025，Vol.40Issue(4)：425-429,5.DOI:10.3969/j.issn.1005-3697.2025.04.004
玻璃体腔注射傲迪适和阿柏西普治疗糖尿病视网膜病变黄斑囊样水肿疗效及对视野灰度值、黄斑厚度和炎症因子的影响
Efficacy of intravitreal injection of ozurdex and aflibercept on cystoid macular edema caused by diabetic retinopathy and its influence on visual field gray value,macular thickness and inflammatory factors
摘要
Abstract
Objective:To compare the efficacy of intravitreal injection of ozurdex and aflibercept in the treatment of cystoid mac-ular edema(CME)caused by diabetic retinopathy(DR)and its influence on visual field gray value,macular thickness and inflamma-tory factors.Methods:The case data of 92 patients(164 eyes)with CME caused by DR were collected,and the above patients were di-vided into ozurdex group(n=47,79 eyes)and aflibercept group(n=45,85 eyes)by treatment methods.The ozurdex group was given injection of ozurdex(0.7 mg),while the aflibercept group was given injection of aflibercept(2 mg).The efficacy,visual acuity,visual field,macular parameters,inflammation and biochemical indexes were evaluated after 3 months of treatment,and the incidence rates of adverse events in the two groups during treatment were counted.Results:The efficacy in ozurdex group was better(P＜0.05),and the light sensitivity was higher than that in aflibercept group(P＜0.05),and the BCVA LogMAR value,visual field gray value,central macular thickness(CRT),total macular volume(TMV),interleukin-1 β(IL-1 β),interleukin-23(IL-23)and monocyte chemoattrac-tant protein-1(MCP-1)were lower(P＜0.05).However,the levels of vascular endothelial growth factor(VEGF)and stromal cell-de-rived factor 1(SDF-1)in aflibercept group were lower(P＜0.05).There were no significant differences in the total incidence rates of adverse events(P＞0.05).Conclusion:Compared with aflibercept,ozurdex has better efficacy in the treatment of CME caused by DR.Ozurdex has rapid visual acuity recovery,obvious improvement of visual field and relieved inflammatory response,but the effect of inhib-iting neovascularization is slightly worse than that of aflibercept.关键词
傲迪适/阿柏西普/糖尿病视网膜病变/黄斑囊样水肿/视野灰度值/黄斑厚度Key words
Ozurdex/Aflibercept/Diabetic retinopathy/Cystoid macular edema/Visual field gray value/Macular thickness分类
临床医学引用本文复制引用
王晓静,潘磊,宁美真,童念庭..玻璃体腔注射傲迪适和阿柏西普治疗糖尿病视网膜病变黄斑囊样水肿疗效及对视野灰度值、黄斑厚度和炎症因子的影响[J].川北医学院学报,2025,40(4):425-429,5.基金项目
国家自然科学基金(81801381) （81801381）
