川北医学院学报2025，Vol.40Issue(4)：442-445,4.DOI:10.3969/j.issn.1005-3697.2025.04.008
盐酸米诺环素联合头孢呋辛酯片治疗对牙周病变患者牙周功能的影响
Effect of combined treatment of minocycline hydrochloride and cefuroxime axetil tablets on periodontal function in patients with periodontal lesions
摘要
Abstract
Objective:To investigate the effect of combined treatment of minocycline hydrochloride and cefuroxime axetil tablets on periodontal function in patients with periodontal lesions.Methods:120 patients with pulp and periodontal lesions were divided into a control group(n=60,basic periodontal treatment+cefuroxime axetil treatment)and an observation group(n=60,control group+mi-nocycline hydrochloride)according to different intervention methods,both treated for4 weeks.The therapeutic efficacy,periodontal clin-ical indices,pain(VAS)score,gingival crevicular fluid inflammatory factors(interleukin-1 β,prostaglandin E2(PGE2),and interleu-kin-8(IL-8)],and the incidence of adverse reactions were compared between the two groups.Results:The overall response rate in the observation group was higher than that in the control group(P＜0.05).After 4 weeks of treatment,both groups exhibited a reduction in gingival bleeding index,probing depth,plaque index,VAS scores,IL-1 β,PGE2,and IL-8(P＜0.05),and the observation group was lower than the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:The combined treatment of minocycline hydrochloride and cefuroxime axetil tablets in patients with periodontal lesions is effective,can effectively improve periodontal function,relieve pain,and reduce inflammatory reactions,and is worth promoting.关键词
盐酸米诺环素/头孢呋辛酯片/牙周病/炎症因子Key words
Minocycline hydrochloride/Cefuroxime axetil tablets/Periodontal disease/Inflammatory factors分类
医药卫生引用本文复制引用
童丽,厚岳森,许蕾..盐酸米诺环素联合头孢呋辛酯片治疗对牙周病变患者牙周功能的影响[J].川北医学院学报,2025,40(4):442-445,4.基金项目
江苏省科技项目(BE2022770) （BE2022770）
