川北医学院学报2025，Vol.40Issue(4)：467-470,4.DOI:10.3969/j.issn.1005-3697.2025.04.014
静脉化疗联合腹腔精准持续热灌注化疗治疗晚期卵巢癌的疗效
Efficacy of intravenous chemotherapy combined with precise continuous circulation intraperitoneal hyperthermic chemotherapy in the treatment of advanced ovarian cancer
摘要
Abstract
Objective:To explore the clinical effects of intravenous chemotherapy combined with IPHC on patients with advanced ovarian cancer(AOC).Methods:Totally 100 patients with AOC were divided into two groups by means of different intervention meth-ods.50 patients in the control group were treated with paclitaxel+carboplatin for intravenous chemotherapy,and the other 50 patients in the observation group were combined with IPHC on the basis of the control group.The clinical efficacy,tumor markers[carcinoembryon-ic antigen(CEA),alpha-fetoprotein(AFP),basic fibroblast growth factor(bFGF),human epididymis protein 4(HE4)],immune cell indicators(CD3+T cell,CD4+T cell,CD4+/CD8+T cell ratio),adverse reactions and survival status were compared between the two groups.Results:After treatment,compared with the control group,the total clinical control rate in the observation group was higher(P＜0.05).The levels of CEA,AFP,bFGF and HE4 in the observation group were lower compared with those in the control group(P＜0.05).The levels of CD3+T cell,CD4+T cell and CD4+/CD8+T cell ratio were higher in the observation group(P＜0.05).There was no statistical significance in the incidence of adverse reactions between groups(P＞0.05).After 12 months of follow-up,the survival curve revealed no statistical difference between both groups(P＞0.05).Conclusion:IPHC combined with TC intravenous chemotherapy has certain efficacy on patients with AOC,and it can reduce the tumor markers and enhance the immune function,and it will not additionally increase adverse reactions.关键词
晚期卵巢癌/精准持续循环腹腔热灌注化疗/静脉化疗/肿瘤标志物Key words
Advanced ovarian cancer/Precise continuous circulation intraperitoneal hyperthermic chemotherapy/Intravenous chemotherapy/Tumor markers分类
临床医学引用本文复制引用
王立霞,姚秀玲,梁焕,刘树雨,戴艳丽..静脉化疗联合腹腔精准持续热灌注化疗治疗晚期卵巢癌的疗效[J].川北医学院学报,2025,40(4):467-470,4.基金项目
河北省医学科学研究课题计划项目(20221493) （20221493）
