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Foundation models in bioinformatics

Fei Guo Renchu Guan Yaohang Li Qi Liu Xiaowo Wang Can Yang Jianxin Wang

国家科学评论（英文版）2025，Vol.12Issue(4)：393-411,19.

国家科学评论（英文版）2025，Vol.12Issue(4)：393-411,19.DOI:10.1093/nsr/nwaf028

Foundation models in bioinformatics

Fei Guo ¹Renchu Guan ²Yaohang Li ³Qi Liu ⁴Xiaowo Wang ⁵Can Yang ⁶Jianxin Wang¹

作者信息

1. Hunan Provincial Key Lab on Bioinformatics,School of Computer Science and Engineering,Central South University,Changsha 410083,China||Xiangjiang Laboratory,Changsha 410083,China
2. Key Laboratory for Symbol Computation and Knowledge Engineering of the Ministry of Education,College of Computer Science and Technology,Jilin University,Changchun 130012,China
3. Department of Computer Science,Old Dominion University,Norfolk 23529,USA
4. School of Life Sciences and Technology,Tongji University,Shanghai 200092,China
5. Department of Automation,Tsinghua University,Beijing 100084,China
6. Department of Mathematics,State Key Laboratory of Molecular Neuroscience,and Big Data Bio-Intelligence Lab,The Hong Kong University of Science and Technology,Hong Kong,China
折叠

摘要

关键词

foundation model/bioinformatics/genomics/transcriptomics/proteomics/drug discovery/single-cell analysis

Key words

foundation model/bioinformatics/genomics/transcriptomics/proteomics/drug discovery/single-cell analysis

引用本文复制引用

Fei Guo,Renchu Guan,Yaohang Li,Qi Liu,Xiaowo Wang,Can Yang,Jianxin Wang..Foundation models in bioinformatics[J].国家科学评论（英文版）,2025,12(4):393-411,19.

基金项目

The work was supported by the National Natural Science Founda-tion of China(62350004,62332020 and 62322215),the Project of Xiangjiang Laboratory(23XJ01011),the National Key Re-search and Development Program of China(2021YFF1201200).The work of Can Yang was supported in part by the Innovation and Technology Commission(ITCPD/17-9)and the Hong Kong University of Science and Technology Z0428 from the Big Data Institute.The work was carried out in part using computing re-sources at the High-Performance Computing Center of Central South University. （62350004,62332020 and 62322215）

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