工程设计学报2025，Vol.32Issue(2)：232-239,8.
基于压电喷墨打印技术的食管支架载药层制备
Preparation of drug-carrying layer of esophageal stent based on piezoelectric inkjet printing technology
摘要
Abstract
Esophageal stenosis is one of the main symptoms of esophageal cancer.Currently,the drug-carrying esophageal stents are widely used in the clinical treatment of esophageal stenosis.At present,the main preparation methods of drug-carrying esophageal stents are dip coating method and spray coating method,but the materials of the drug-carrying layer of esophageal stent prepared by these methods were limited and the coating accuracy is not high.To solve the above problems,a method for preparing the drug-carrying layer of esophageal stent based on piezoelectric inkjet printing technology is proposed.Firstly,the finite element simulation method was used to design the temperature control box for the piezoelectric inkjet printing platform and optimize the temperature control parameters,so as to promote the solidification of printing materials and broaden the materials used in the drug-carrying layer.Then,the influence of voltage amplitude,slope parameter and pulse width of the driving waveform for piezoelectric inkjet heads on the droplet diameter was deeply explored,and the driving waveform parameters were optimized to improve the coating accuracy of drug-carrying layer.Finally,the printing experiment for drug-carrying layer was conducted to verify the accuracy and effectiveness of the simulation design of temperature control box and the optimization of driving waveform parameters.The results showed that the GelMA(gelatin methacryloyl)hydrogel had a good forming effect at-4 to 4℃.The droplet diameter was positively correlated with the voltage amplitude and slope parameters of the driving waveform,but there was an optimal pulse width.Under the premise of ensuring printing accuracy,the rising edge voltage amplitude was determined to be 30 V,the rising edge slope and the falling edge slope were both 7 V/ms,and the pulse width was 1.5 ms.Using this driving waveform,a uniform drug-carrying layer of esophageal stent with good curing and forming effect and high accuracy was successfully printed,which could provide a new idea for the preparation of drug-carrying esophageal stents.关键词
食管支架/喷墨打印/驱动波形/液滴直径/GelMA水凝胶Key words
esophageal stent/inkjet printing/driving waveform/droplet diameter/GelMA hydrogel分类
信息技术与安全科学引用本文复制引用
郑跃靖,梁文峰,王婷婷,李松,朱慧轩,张凯..基于压电喷墨打印技术的食管支架载药层制备[J].工程设计学报,2025,32(2):232-239,8.基金项目
国家自然科学基金资助项目(52205319) （52205319）
中国科学院青年创新促进会项目(2021200) （2021200）
辽宁省教育厅基本科研项目(JYTQN2023025) （JYTQN2023025）
沈阳市中青年科技创新人才支持计划项目(RC220482) （RC220482）
盛京345人才支持计划资助项目(M1317) （M1317）
