国际医药卫生导报2025，Vol.31Issue(8)：1254-1257,4.DOI:10.3760/cma.j.cn441417-20241205-08005
基质金属蛋白酶及基质金属蛋白酶抑制剂在慢性鼻窦炎中的影响
Effects of matrix metalloproteinases and matrix metalloproteinase inhibitors on chronic sinusitis
摘要
Abstract
Chronic sinusitis(CRS)is a chronic inflammation of nasal cavity and sinus mucosa.According to its clinical manifestations,it can be divided into chronic sinusitis without nasal polyps(CRSsNP)and chronic sinusitis with nasal polyps(CRSwNP).The current conservative treatment effect is not good,and the postoperative recurrence rate is high,which greatly affects the patients'quality of life.The pathogenesis of CRS may be related to the destruction of nasal mucosa epithelium,tissue remodeling,bacterial infection,and other factors.At present,studies show that tissue remodeling plays an important role in the occurrence and development of CRS.Abnormal degradation of extracellular matrix(ECM)is a part of tissue remodeling,in which matrix metalloproteinases(MMPs)and matrix metalloproteinase inhibitors(TIMPs)are the key factors regulating ECM metabolism.Therefore,this paper summarizes the influence of MMPs and TIMPs on CRS.关键词
慢性鼻窦炎/鼻息肉/基质金属蛋白酶/基质金属蛋白酶抑制剂/组织重塑/综述Key words
Chronic sinusitis/Nasal polyp/Matrix metalloproteinases/Matrix metalloproteinase inhibitors/Tissue remodeling/Review引用本文复制引用
苗森皓,李秀国..基质金属蛋白酶及基质金属蛋白酶抑制剂在慢性鼻窦炎中的影响[J].国际医药卫生导报,2025,31(8):1254-1257,4.基金项目
国家自然科学基金(82371118) （82371118）
山东省自然科学基金(ZR2019BH019) National Natural Science Foundation(82371118) （ZR2019BH019）
Shandong Provincial Natural Science Foundation(ZR2019BH019) （ZR2019BH019）
