国际医药卫生导报2025，Vol.31Issue(8)：1260-1265,6.DOI:10.3760/cma.j.cn441417-20241118-08007
胸苷酸合成酶基因在肿瘤发生发展中的研究进展
Research progress of thymidylate synthase gene in tumorigenesis and development
摘要
Abstract
Protein encoded by the thymidylate synthase(TYMS)gene is a rate-limiting enzyme necessary for DNA synthesis and is an important enzyme for DNA damage repair,and plays an important role in a variety of physiological and pathological conditions.This article mainly reviews the expression and clinical significance of TYMS gene in various types of tumors,the effect and mechanism of TYMS gene on the malignant biological behaviors and the sensitivity to chemotherapeutic drugs of tumor cells,various factors regulating TYMS gene expression,and the anti-tumor application of TYMS gene targeting.关键词
肿瘤/胸苷酸合成酶/发生/发展/机制/进展Key words
Tumor/Thymidylate synthase/Tumorigenesis/Development/Mechanism/Progress引用本文复制引用
洪金全,黄震宇,黄惠炆,黄豪博..胸苷酸合成酶基因在肿瘤发生发展中的研究进展[J].国际医药卫生导报,2025,31(8):1260-1265,6.基金项目
福建省科技创新联合资金(2019Y9050) Joint Fund for Innovation of Science and Technology in Fujian province(2019Y9050) （2019Y9050）
