国际医药卫生导报2025，Vol.31Issue(8)：1265-1269,5.DOI:10.3760/cma.j.cn441417-20240621-08008
自噬与缺血性脑血管疾病的研究进展
Research progress on autophagy and ischemic cerebrovascular diseases
摘要
Abstract
Ischemic cerebrovascular disease(ICVD)is a disease that seriously endangers human health,and it has the characteristics of acute onset,disability,and high mortality rate.In recent years,the incidence rate has been increasing year by year,and the age of onset is getting younger and younger.Autophagy is a life phenomenon unique to eukaryotes in self-repairing processes,and is a physiological process in which lysosomes in cells degrade phagocytoses.Studies have found that autophagy can be activated after ischemic brain injury,which affects protein expression and internal environment,thereby accelerating or stopping the progression of ICVD.The two-sided nature of autophagy is still unclear,and moderate regulation of autophagy activation may be the key to the protective role of autophagy.This article discusses the related contents of ICVD,autophagy,and the possible protective and damaging effects of autophagy in ICVD,in order to provide new solutions and targets for the diagnosis and treatment of ICVD.关键词
自噬/动脉粥样硬化/信号通路/缺血性脑血管疾病/进展Key words
Autophagy/Atherosclerosis/Signal path/Ischemic cerebrovascular disease/Progress引用本文复制引用
蒋萌,赵静如,刘惠,刘庆新..自噬与缺血性脑血管疾病的研究进展[J].国际医药卫生导报,2025,31(8):1265-1269,5.基金项目
山东省医药卫生科技发展计划(2017WS157) （2017WS157）
滨州医学院科研计划与科研启动基金(BY2019KJ07) Health Science and Technology Development Program of Shandong Province(2017WS157) （BY2019KJ07）
Research Plan and Research Start-up Fund of Binzhou Medical University(BY2019KJ07) （BY2019KJ07）
