国际医药卫生导报2025，Vol.31Issue(8)：1311-1315,5.DOI:10.3760/cma.j.cn441417-20240919-08017
超声影像学特征联合TgAb、TSH鉴别甲状腺结节良恶性的价值
Value of ultrasound imaging features combined with TgAb and TSH for differentiating benign and malignant thyroid nodules
摘要
Abstract
Objective To analyze the ultrasound imaging features combined with thyroglobulin antibody(TgAb)and thyroid stimulating hormone(TSH)for differentiating benign and malignant thyroid nodules.Methods A total of 85 patients with thyroid nodules admitted to Shaanxi Provincial Hospital of Traditional Chinese Medicine from May 2021 to June 2024 were selected as the study objects,Among them,42 were males and 53 were females.All the patients underwent ultrasound examination.The serum levels of TgAb and TSH were detected by the automatic chemiluminescence analyzer.According to the pathological examination results,the patients were divided into a benign nodule group and a malignant nodule group.The ultrasound imaging features and levels of TgAb and TSH were compared between the two groups.t and x2 tests were used for the statistical analysis.The influence factors of malignancy in the patients were analyzed by the binary logistic step-by-step regression model.The value of ultrasound imaging features combined with TgAb and TSH for differentiating benign and malignant thyroid nodules was analyzed by the receiver operating characteristic curve(ROC).Results There were 95 nodules in the 85 patients;there were 69 benign nodules(72.63％),including 51 nodular thyroid tumors,12 adenomas,and 6 inflammatory nodules;there were 26 malignant nodules(27.37％),including 22 papillary carcinoma,2 medullary carcinoma,and 2 follicular carcinoma.There were statistical differences in the nodule maximum diameter,shape,blood flow grading,and levels of TgAb and TSH between the two groups(all P＜0.05).The binary logistic regression analysis showed that the nodule maximum diameter＞10 mm[OR=5.513(95％CI 1.960-15.505)],irregular shape[OR=4.807(95％CI 1.814-12.739)],grade 2-3 blood flow[OR=3.960(95％CI 1.506-10.412)],TgAb level[OR=1.076(95％CI 1.036-1.117)],and TSH level[OR=2.635(95％CI 1.627-4.270)]were the influential factors for diagnosing malignancy in the patients(all P＜0.05).The ROC showed that the sensitivities of nodule maximum diameter＞10 mm,irregular shape,grade 2-3 blood flow,TgAb level,and TSH level in the diagnosis of malignant nodules in the patients were 0.769,0.692,0.692,0.808,0.731 and 0.885,respectively;the specificities were 0.623,0.681,0.638,0.623,0.638 and 0.870,respectively.Their combination for diagnosing malignancy in the patients had higher value(the area under curve=0.881).Conclusion Ultrasound imaging features combined with TgAb and TSH are of high value in the diagnosis of patients with malignant thyroid nodules,and can improve the differential diagnosis efficiency.关键词
甲状腺结节/超声影像学特征/甲状腺球蛋白抗体/促甲状腺激素/鉴别Key words
Thyroid nodules/Ultrasound imaging features/Thyroglobulin antibody/Thyroid stimulating hormone/Differentiation引用本文复制引用
杨金艳,马哲,徐华..超声影像学特征联合TgAb、TSH鉴别甲状腺结节良恶性的价值[J].国际医药卫生导报,2025,31(8):1311-1315,5.基金项目
国家卫健委"十四五"规划全国重点课题(YWS4188) National Key Project of 14th Five-year Plan of National Health Commission(YWS4188) （YWS4188）
