国际医药卫生导报2025，Vol.31Issue(8)：1327-1331,5.DOI:10.3760/cma.j.cn441417-20241113-08020
扩大淋巴结清扫胰十二指肠切除手术治疗胰腺癌患者的效果
Effect of extended lymph node dissection pancreaticoduodenectomy for patients with pancreatic adenocarcinoma
摘要
Abstract
Objective To investigate the effect of extended lymph node dissection pancreaticoduodenectomy(PD)for patients with pancreatic adenocarcinoma.Methods Seventy-eight patients with pancreatic adenocarcinoma treated in Nanyang Second People's Hospital from January 2020 to December 2023 were selected for the randomized controlled trial,and were divided into an extended dissection group and a standard dissection group by the random number table method,with 39 cases in each group.There were 22 males and 17 females in the expanded dissection group;they were(59.85±3.26)years old;their body mass index was(22.71±1.08)kg/m2;the maximum tumor diameter was(3.38±1.01)cm.There were 24 males and 15 females in the standard dissection group;they were(60.05±3.34)years old;their body mass index was(22.78±1.12)kg/m2;the maximum tumor diameter was(3.40±0.97)cm.Both groups were treated with PD;the standard dissection group took standard lymph node dissection,and the extended dissection group extended lymph node dissection.The intraoperative indicators(operation time,intraoperative bleeding volume,intraoperative blood transfusion volume,total number of lymph node dissection,and number of positive lymph node dissection),postoperative recovery indicators(time to get out of bed,time for first liquid diet,time to drainage tube extraction,and hospital stay),incidence rates of complications,lymph node metastasis rates,in situ recurrence rates,and survival rates were compared between the two groups.x2 and t tests were used for the statistical analysis.Results The operation time,intraoperative bleeding volume,intraoperative blood transfusion volume,total number of lymph node dissection,and number of positive lymph node dissection in the extended dissection group were(401.36±38.90)min,(293.66±31.68)ml,(145.89±22.17)ml,24.41±4.33,and 13.69±2.12;those in the standard dissection group were(376.52±33.22)min,(276.85±29.41)ml,(133.34±20.64)ml,16.98±3.86,and 11.12±2.05;there were statistical differences(all P＜0.05).There were no statistical differences in the time to get out of bed,time for first liquid diet,time to drainage tube extraction,hospital stay,total incidence rate of complications,lymph node metastasis rate,in situ recurrence rate,and survival rate between the two groups(all P＞0.05).Conclusion Extended lymph node dissection PD for patients with pancreatic adenocarcinoma can increase the total number of lymph node dissection and the number of positive lymph node dissection,but will increase the surgical trauma and prolong the surgical time,and can not improve the survival rate.关键词
胰腺癌/扩大淋巴结清扫/胰十二指肠切除手术/围手术期指标/并发症/预后Key words
Pancreatic adenocarcinoma/Extended lymph node dissection/Pancreaticoduodenectomy/Perioperative indicators/Complications/Prognosis引用本文复制引用
李广洲,王红雷,贺洋,胡翠,陈艳浩..扩大淋巴结清扫胰十二指肠切除手术治疗胰腺癌患者的效果[J].国际医药卫生导报,2025,31(8):1327-1331,5.基金项目
河南省医学科技攻关计划(LHGJ20210977) （LHGJ20210977）
南阳市第二人民医院2024年院级科研立项(6) Problem-tackling Plan of Medical Science and Technology in Henan(LHGJ20210977) （6）
Scientific Research Project of Nanyang Second People's Hospital in 2024(6) （6）
