国际医药卫生导报2025，Vol.31Issue(8)：1342-1348,7.DOI:10.3760/cma.j.cn441417-20241114-08023
芪龙通络汤联合针刺治疗糖尿病周围神经病变患者的效果
Effect of Qilong Tongluo Decoction combined with acupuncture for patients with diabetic peripheral neuropathy
摘要
Abstract
Objective To observe the effect of Qilong Tongluo Decoction and acupuncture in the treatment of patients with diabetic peripheral neuropathy(DPN).Methods A total of 86 patients with.DPN treated at Shaanxi Provincial Hospital of Traditional Chinese Medicine from September 2021 to September 2023 were selected for the randomized controlled trial,including 46 males and 40 females.They were 28-75 years old.Their DPN course was 1-10 years.Twenty cases had coronary heart disease,32 hyperlipidemia,and 8 retinopathy.Their body mass index was 19.68-26.84 kg/m2.They were divided into an acupuncture group and an acupuncture-drug group by the random number table method,with 43 cases in each group.Both groups were given symptomatic western medicine treatment.The acupuncture group took acupuncture on the Baliao and Bafeng points.The acupuncture-drug group were given Qilong Tongluo decoction and acupuncture on Baliao and Bafeng points.Both groups were treated for 4 weeks.The numbers of intestinal flora,the relative protein expressions of the kelch-like ECH-associated protein 1(Keap1)/nuclear factor E2 related factor 2(Nrf2)/anti oxidant response element(ARE)of the mononuclear cell pathway,oxidative stress factors,common carotid artery pressure strain elastic modulus(Ep),nerve conduction,and scores of traditional Chinese medicine symptom were compared between the two groups by t test.Results After the treatment,the number of the Fusobacterium flora in the acupuncture-drug group was higher than that in the acupuncture group[(10.25±1.20)cfu/g vs.(8.23±1.14)cfu/g;P＜0.05],while the number of Bacteroides flora was lower[(7.57±0.61)cfu/g vs.(8.96±0.74)cfu/g;P＜0.05].After the treatment,the relative expressions of Nrf2,ARE,and NAD(P)H:quinone oxidoreductase 1(NQO1)in the acupuncture-drug group were higher than those in the acupuncture group(1.39±0.31 vs.1.10±0.28,0.98±0.14 vs.0.81±0.11,and 1.73±0.31 vs.1.42±0.28;all P＜0.05);the relative expression of Keap1 in the acupuncture-drug group was lower than that in the acupuncture group(0.43±0.12 vs.0.59±0.14;P＜0.05).After the treatment,the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX)in the acupuncture-drug group were higher than those in the acupuncture group[(85.56±8.65)U/ml vs.(78.41±9.44)U/ml and(278.85±38.96)U/ml vs.(249.56±32.06)U/ml;both P＜0.05];the common carotid artery Ep,score of traditional Chinese medicine symptom,and level of malondialdehyde(MDA)in the acupuncture-drug group were lower than those in the acupuncture group[(115.12±5.98)kPa vs.(124.65±8.75)kPa,9.44±1.46 vs.13.25±2.14,and(4.15±0.53)μmol/L vs.(4.82±0.74)μmol/L;all P＜0.05].After the treatment,the sensory nerve conduction velocity(SNCV)and motor nerve conduction velocity(MNCV)of median nerve and common peroneal nerve in the acupuncture-drug group were higher than those in the acupuncture group[(53.47±4.22)m/s vs.(49.58±4.36)m/s,(50.97±3.06)m/s vs.(48.75±3.12)m/s,(52.89±4.26)m/s vs.(50.66±4.01)m/s,and(50.63±3.75)m/s vs.(48.79±3.14)m/s;all P＜0.05].Conclusion The combination of Qilong Tongluo Decoction and acupuncture for patients with DPN can relieve their symptoms and improve their nerve conduction velocity,which may be related to the regulation of the Keap1/Nrf2/ARE pathway and intestinal flora.关键词
芪龙通络汤/针刺/氧化应激/神经传导速度/肠道菌群/糖尿病周围神经病变Key words
)Qilong Tongluo Decoction/Acupuncture/Oxidative stress/Nerve conduction velocity/Intestinal flora/Diabetic peripheral neuropathy引用本文复制引用
刘亚东,雷芳,邱筱娜..芪龙通络汤联合针刺治疗糖尿病周围神经病变患者的效果[J].国际医药卫生导报,2025,31(8):1342-1348,7.基金项目
陕西省重点研发计划(2022SF-204) Key Plan of Research and Development in Shaanxi(2022SF-204) （2022SF-204）
