广西中医药2025，Vol.48Issue(2)：10-14,5.
复方江南卷柏汤联合西药治疗湿热蕴结型急性痛风性关节炎临床观察
Clinical observation of compound Jiangnanjuanbai decoction combined with western medicine treating acute gouty arthritis with damp-heat accumulation syndrome
摘要
Abstract
Objective:To evaluate the clinical efficacy of compound Jiangnanjuanbai decoction,when used in combination with diclofenac sodium sustained-release capsules,in treating acute gouty arthritis(AGA)with a damp-heat accumulation syndrome.Methods:A total of 120 patients diagnosed with AGA and presenting with damp-heat ac-cumulation syndrome were randomly allocated into three groups:control group,traditional Chinese medicine(TCM)group,and integrated TCM-Western medicine group,with 40 patients in each group.Patients in the control group re-ceived oral diclofenac sodium sustained-release capsules,those in the TCM group were orally administered compound Jiangnanjuanbai decoction,and patients in the integrated group received both treatments concurrently.The treatment in all groups lasted for one week.Visual analog scale(VAS)scores for pain,TCM syndrome scores(including joint swelling,joint pain,and joint burning sensation),and levels of serum uric acid(UA)as well as levels of inflammatory markers,including white blood cell(WBC)count,C-reactive protein(CRP)levels,and erythrocyte sedimentation rate(ESR)were measured before and after the treatment.The therapeutic outcomes and the incidence of adverse reactions were compared across the three groups.Result:The total effective rates were 77.5%in the control group,75.0%in the TCM group,and 85.0%in the integrated group.No significant differences in efficacy were observed among the three groups(P＞0.05).Following treatment,all three groups demonstrated reductions in pain VAS scores,TCM syndrome scores,UA levels,and inflammatory marker levels.Notably,the integrated group exhibited significantly lower pain VAS scores,joint swelling scores,joint pain scores,CRP levels,and ESR levels compared to the control and TCM group,and lower UA levels compared to the control group(all P＜0.05).The incidence of adverse reactions was 2.5%in all three groups,with no statistically significant differences among them(P＞0.05).Conclusion:The combination thera-py of compound Jiangnanjuanbai decoction and diclofenac sodium sustained-release capsules demonstrates significant efficacy in alleviating clinical symptoms,reducing UA levels,inhibiting inflammatory responses,and exhibits a favor-able safety in the treatment of acute gouty arthritis with a damp-heat accumulation syndrome.This integrated approach is worthy of further promotion in clinical practice.关键词
急性痛风性关节炎/复方江南卷柏汤/湿热蕴结型/临床观察Key words
acute gouty arthritis/compound Jiangnanjuanbai decoction/damp-heat accumulation syndrome/clini-cal observation分类
医药卫生引用本文复制引用
胡浩,戴新华,张梦婷..复方江南卷柏汤联合西药治疗湿热蕴结型急性痛风性关节炎临床观察[J].广西中医药,2025,48(2):10-14,5.基金项目
黄冈市级科技创新专项前资助项目(编号:YBXM20240044) （编号:YBXM20240044）
