临床与病理杂志2025，Vol.45Issue(1)：18-24,7.DOI:10.11817/j.issn.2095-6959.2025.240649
FNAC联合BRAFV600E基因突变检测在甲状腺乳头状癌诊断中的价值及临床意义
Value and clinical significance of FNAC combined with BRAFV600E gene mutation detection in diagnosing papillary thyroid carcinoma
周晋星 1吴妍 1席雷 1邹子归 2翟博雅 1戎荣1
作者信息
- 1. 南京医科大学第一附属医院,江苏省人民医院病理学部,南京 210029
- 2. 苏州大学附属第一医院病理科,苏州 215006
- 折叠
摘要
Abstract
Objective:Papillary thyroid carcinoma(PTC)is the most common malignant tumor of the thyroid.This study aims to evaluate the value of BRAFV600E gene mutation detection combined with fine needle aspiration cytology(FNAC)in the diagnosis of PTC and explore the correlation between BRAFV600E gene mutation and clinical pathological characteristics of PTC.
Methods:A retrospective analysis was conducted on the clinical pathological data of 2 268 patients who underwent both FNAC and BRAFV600E molecular testing and were confirmed to have PTC by postoperative histopathology from January 2019 to December 2022.The relationship between BRAFV600E gene mutation and clinical pathological factors were analyzed,and the differences in mutation detection rates between preoperative FNAC and postoperative paraffin samples were compared.
Results:Compared with FNAC or BRAFV600E gene mutation detection alone,the combination of FNAC and BRAFV600E mutation detection significantly improved the sensitivity,negative predictive value,and accuracy in diagnosing thyroid nodules(all P<0.05).There was no significant difference in the BRAFV600E gene mutation detection rate between preoperative FNAC samples and postoperative paraffin samples.The BRAFV600E gene mutation was associated with the age of PTC patients,tumor size≤1 cm,classic subtype,unilaterality,multifocality,no lymph node metastasis,no tumor thrombus in the vascular vein or neural invasion,and the absence of lymphocytic thyroiditis(all P<0.05),but was not associated with gender,capsular invasion,or T stage(all P>0.05).
Conclusion:The combination of FNAC and BRAFV600E gene mutation detection can significantly improve the diagnostic accuracy of thyroid nodules.The mutation detection efficiency is similar whether preoperative FNAC or postoperative paraffin samples are used.The BRAFV600E mutation does not indicate a poorer prognosis for PTC patients,but it can serve as an effective adjunctive examination method for diagnosing PTC.关键词
BRAFV600E基因/细针穿刺细胞学检查/甲状腺/乳头状癌/超声引导Key words
BRAFV600E gene/fine needle aspiration cytology/thyroid/papillary carcinoma/ultrasonic guidance引用本文复制引用
周晋星,吴妍,席雷,邹子归,翟博雅,戎荣..FNAC联合BRAFV600E基因突变检测在甲状腺乳头状癌诊断中的价值及临床意义[J].临床与病理杂志,2025,45(1):18-24,7.
