临床与病理杂志2025，Vol.45Issue(1)：46-54,9.DOI:10.11817/j.issn.2095-6959.2025.240689
老年急诊创伤患者衰弱现状及其危险因素
Frailty status and risk factor analysis in elderly emergency trauma patients
摘要
Abstract
Objective:With the continuous aging of the population,the number of elderly emergency trauma patients has increased.Frailty significantly increases the risk of poor prognosis in these patients,and early identification and intervention can improve clinical outcomes.This study aims to investigate the frailty status in elderly emergency trauma patients and analyze the associated risk factors,providing a basis for screening high-risk frailty populations. Methods:A total of 306 elderly trauma patients treated in the emergency departments of the First Affiliated Hospital and the Second Affiliated Hospital of University of South China from December 2023 to June 2024 were selected.Basic information,trauma status,and laboratory indicators were collected.The Trauma-Specific Frailty Index(TSFI)was used to assess frailty status.Logistic regression analysis was conducted to explore the risk factors for frailty in elderly emergency trauma patients. Results:Among the 306 patients,216 were male,and 90 were female,with a median age of 68.00(64.00,73.00)years.The median TSFI score was 0.23(0.22,0.40),with 152(49.67%)patients classified as frail and 154(50.33%)patients as non-frail.Univariate analysis showed significant differences in red blood cell count,serum albumin,age,heart rate,Glasgow Coma Scale(GCS),Injury Severity Score(ISS),white blood cell count,neutrophil count,hemoglobin,blood lactate,C-reactive protein,D-dimer,interleukin-6,number of chronic diseases,head and neck trauma,chest trauma,abdominal trauma,multiple injuries,post-traumatic shock,emergency transfusion,trauma causes,and other factors between the frail and non-frail patients(all P<0.05).Multivariate logistic regression analysis showed that older age,more chronic diseases,higher ISS scores,head and neck trauma,decreased hemoglobin levels,lower serum albumin levels,elevated interleukin-6 levels,and higher blood lactate levels were independent risk factors for frailty in elderly emergency trauma patients(all P<0.05). Conclusion:Frailty occurs at a high rate in elderly emergency trauma patients.Older age,more chronic diseases,higher ISS,head and neck trauma,decreased hemoglobin levels,lower serum albumin levels,elevated interleukin-6 levels,and higher blood lactate levels are independent risk factors for frailty in these patients.Clinical healthcare providers should intervene based on these risk factors to reduce frailty occurrence and improve the prognosis of elderly trauma patients.关键词
老年人/急诊/创伤/衰弱/创伤特异性衰弱指数/损伤严重程度评分/危险因素Key words
elderly/emergency/trauma/frailty/Trauma-Specific Frailty Index/Injury Severity Score/risk factors引用本文复制引用
高悦,尹心红,陈可,蒋丹丹,佘柯仪,张红涛,阳欣君,张雯,周雨彤,陈尧..老年急诊创伤患者衰弱现状及其危险因素[J].临床与病理杂志,2025,45(1):46-54,9.基金项目
湖南省自然科学基金(2024JJ6400,2023JJ30528) （2024JJ6400,2023JJ30528）
湖南省卫生健康委一般指导课题(D202314058794) （D202314058794）
大学生创新创业训练计划(230XCX250) （230XCX250）
衡阳市社会科学基金(2023D009).This work was supported by the Natural Science Foundation of Hunan Province(2024JJ6400,2023JJ30528),the General Guiding Project of Health Committee of Hunan Province(D202314058794),the College Student Innovation and Entrepreneurship Training Program(230XCX250),and the Social Science Foundation of Hengyang(2023D009),China. （2023D009）
