临床与病理杂志2025，Vol.45Issue(1)：65-73,9.DOI:10.11817/j.issn.2095-6959.2025.241086
血管周围脂肪组织参与动脉粥样硬化发病机制的研究进展
Research progress in the role of perivascular adipose tissue in the pathogenesis of atherosclerosis
摘要
Abstract
Perivascular adipose tissue(PVAT)surrounds most blood vessels in the body,excluding the brain vasculature,capillaries,and micro-vessels in the alveoli,and has become an important active component of the vascular wall.PVAT has a complex tissue structure,containing various cell types such as mature adipocytes,mesenchymal stem cells,fibroblasts,and vascular smooth muscle cells,along with abundant extracellular matrix.These structures not only provide necessary mechanical support for blood vessels but also significantly impact vascular function and morphology by secreting various bioactive molecules,including adipokines,cytokines,and exosomes.PVAT is a hybrid of white adipose tissue and brown adipose tissue with regional differences.Under normal physiological conditions,the protective adipokines secreted by PVAT play a positive role in resisting atherosclerosis(AS).However,under pathological conditions such as obesity or metabolic disorders,the role of PVAT may reverse and become a source of pro-inflammatory factors,thereby promoting the development of AS.Given the core regulatory role of PVAT in the progression of AS,it may become a target for the prevention and treatment of AS in the future.关键词
血管周围脂肪组织/动脉粥样硬化/细胞因子/脂肪因子/外泌体Key words
perivascular adipose tissue/atherosclerosis/cytokines/adipokines/exosomes引用本文复制引用
赵涵,强红丽,陈倍望,贾辛未..血管周围脂肪组织参与动脉粥样硬化发病机制的研究进展[J].临床与病理杂志,2025,45(1):65-73,9.基金项目
河北省医学适用技术跟踪项目(GZ2023051) （GZ2023051）
研究生创新能力培养资助项目(HBU2025BS007).This work was supported by the Medical Applicable Technology Tracking Project of Hebei Province(GZ2023051)and the Graduate Innovation Ability Training Funding Project(HBU2025BS007),China. （HBU2025BS007）
