临床与病理杂志2025，Vol.45Issue(1)：74-84,11.DOI:10.11817/j.issn.2095-6959.2025.240172
肺神经内分泌细胞与支气管哮喘
Pulmonary neuroendocrine cells and bronchial asthma
摘要
Abstract
Bronchial asthma is a pulmonary disease caused by chronic airway inflammation.Pulmonary neuroendocrine cells(PNECs)are rare epithelial cells with both neural and endocrine functions.This article explores the structure and function of PNECs,focusing on the neuropeptides and pathway mediators they secrete and their roles in the pathogenesis of bronchial asthma.PNECs are innervated and possess membrane receptors sensitive to environmental stimuli.Upon exposure to allergens,PNECs release various bioactive amines and neuropeptides,among which calcitonin gene-related peptide(CGRP)and gamma-aminobutyric acid(GABA)are closely associated with asthma onset,participating in airway inflammatory responses and mucus hypersecretion,respectively.Targeted regulation of PNEC activity and related signaling pathways,by mediating the interactions between PNECs and various effector cells and bioactive substances in the airway microenvironment,may play a crucial role in modulating asthma pathogenesis and developing targeted therapeutic strategies.In traditional Chinese medicine,asthma is believed to result from the internal and external pathogenic factors causing a reversal of lung qi and impaired dispersing and descending functions.Traditional Chinese medicine treatment often combines internal and external therapies to relieve cough and asthma symptoms.With a long history and proven effectiveness,traditional Chinese medicine complements the limitations of Western medicine,providing a more comprehensive approach to asthma management.This review summarizes the role of PNECs in asthma and the advances in both traditional Chinese medicine and Western medicine treatments,offering new insights into asthma prevention and therapy.关键词
肺神经内分泌细胞/降钙素基因相关肽/2型固有淋巴细胞/γ-氨基丁酸/黏蛋白5ac/支气管哮喘Key words
pulmonary neuroendocrine cells/calcitonin gene-related peptide/type 2 innate lymphoid cells/gamma-aminobutyric acid/mucin 5ac/bronchial asthma引用本文复制引用
王东琳,曲妮妮..肺神经内分泌细胞与支气管哮喘[J].临床与病理杂志,2025,45(1):74-84,11.基金项目
高等学校基本科研项目{辽教办[2021]454号}.This work was supported by the Basic Research Projects for Universities,China(Liaojiao Office[2021]No.454). （Liaojiao Office[2021]No.454）
