临床与病理杂志2025，Vol.45Issue(1)：116-121,6.DOI:10.11817/j.issn.2095-6959.2025.240623
直肠腺瘤样腺癌伴宫颈及阴道转移1例
A case of adenoma-like adenocarcinoma with cervical and vaginal metastasis
摘要
Abstract
This study aims to explore the clinicopathological features,immunohistochemistry,and diagnostic and differential diagnostic key points of rectal adenoma-like adenocarcinoma.We report a case of an elderly female patient who was admitted to Hainan Provincial People's Hospital in 2022 due to"bloody stool with prolapsed anal mass for over a year."In 2022 and 2024,cervical and vaginal tumors were biopsied and sent for histological examination.The tumors were diagnosed as metastatic rectal adenoma-like adenocarcinoma.Histological and immunophenotypic features of rectal,cervical,and vaginal tumor tissues were observed.The tumors in all sites showed similar histological patterns to villous-tubular adenomas,with atypical glandular epithelium growing in a villous pattern and mild atypical hyperplasia of the epithelium.The tumor tissues exhibited pushing growth.Immunohistochemistry showed that tumor cells were positive for caudal-related homeobox transcription factor(CDX2)and specific AT sequence binding protein 2(SATB-2),but negative for suppressor gene protein 16(P16).Adenoma-like adenocarcinoma is a rare disease,often misdiagnosed as an adenoma,and cases with cervical and vaginal metastasis are even rarer.It is easily confused with cervical tumors,and a clear diagnosis requires careful correlation with clinical history and immunophenotype.关键词
结直肠肿瘤/腺瘤样腺癌/临床病理特征/免疫组织化学/鉴别诊断Key words
colorectal tumors/adenoma-like adenocarcinoma/clinicopathological features/immunohistochemistry/differential diagnosis引用本文复制引用
尹腊梅,刘富金,王波..直肠腺瘤样腺癌伴宫颈及阴道转移1例[J].临床与病理杂志,2025,45(1):116-121,6.基金项目
海南省重大科技计划(ZDYF2021SHFZ247) （ZDYF2021SHFZ247）
海南省自然科学基金青年基金(820QN387).This work was supported by the Major Science and Technology Program of Hainan Province(ZDYF2021SHFZ247)and the Natural Science Foundation for Young Scientists Project of Hainan Province(820QN387),China. （820QN387）
