口腔疾病防治2025，Vol.33Issue(5)：401-408,8.DOI:10.12016/j.issn.2096-1456.202440350
牙龈卟啉单胞菌与白色念珠菌交互作用在口腔疾病中的研究进展
Research progress on the microbial interaction between Porphyromonas gingivalis and Candida albicans in oral diseases
摘要
Abstract
The human oral microbiota includes over 700 microorganisms such as fungi,bacteria,archaebacteria,and viruses.The interaction between fungi and bacteria,as well as their impact on the host immune system,is currently a popular topic in the field of oral disease research.Porphyromonas gingivalis(P.g)is the key pathogenic bacterium of chronic periodontitis,while Candida albicans(C.a)is a common opportunistic pathogen.P.g and C.a are associated with various oral diseases.A review of the literature suggests that P.g and C.a synergistically increase the amount of biofilm.They adhere to each other,promoting the formation of mixed biofilms.At the same time,C.a can utilize its dense hy-phae and metabolic activities to consume oxygen,providing a low-oxygen microenvironment for P.g,thereby enhancing its vitality and virulence.C.a and P.g can also enhance their virulence through heme competition mechanisms and main-tain the normal morphology of P.g by extracellular polysaccharides.In addition,P.g and C.a can synergistically invade the host and escape from the host's immune system,ultimately leading to a state of chronic infection in the host.Based on the interactions of P.g and C.a,numerous studies on prevention and treatment strategies have been conducted,in-cluding those of various composite materials and natural plants.However,such drugs are mostly limited to phenotypes and suffer from poor selectivity,thus resulting in a lack of specific drugs and research on their mechanisms.This review aims to explore the latest advances in the bacterial-fungal interactions,highlighting the roles of P.g and C.a in oral dis-eases,emphasizing the importance of developing treatment strategies for co-infection of P.g and C.a,and providing new ideas for the prevention and treatment of related diseases.关键词
牙龈卟啉单胞菌/白色念珠菌/细菌/真菌/交互作用/牙周炎/种植体周围炎/口腔黏膜炎/免疫应答/免疫逃逸Key words
Porphyromonas gingivalis/Candida albicans/bacterial/fungal/interaction/periodontitis/peri-implantitis/oral mucositis/immune response/immune escape分类
口腔医学引用本文复制引用
王雨薇,邹玲..牙龈卟啉单胞菌与白色念珠菌交互作用在口腔疾病中的研究进展[J].口腔疾病防治,2025,33(5):401-408,8.基金项目
国家自然科学基金面上项目(82071111) This work was supported by the National Natural Science Foundation of China(No.82071111). （82071111）
