口腔疾病防治2025，Vol.33Issue(5)：417-424,8.DOI:10.12016/j.issn.2096-1456.202440418
低强度脉冲超声促进牙种植体骨结合的研究进展
Research progress on low-intensity pulsed ultrasound in promoting osseointegration of dental implants
摘要
Abstract
How to effectively promote osseointegration of dental implants remains a pressing clinical challenge.Low-intensity pulsed ultrasound(LIPUS)has demonstrated remarkable efficacy in accelerating the healing of various bodily tissues,including bone tissue.In recent years,there has been extensive research on its application in promoting osseoin-tegration in the field of dental implantology.Animal studies have shown that LIPUS exhibits significant potential in facil-itating osseointegration of dental implants.In vitro experiments have further revealed that LIPUS can enhance the ex-pression of key osteogenic factors,extracellular matrix mineralization,and induce local neurons to secrete αCGRP.Through the regulation of signaling pathways such as bone morphogenetic protein/Smad(Bmp/Smad),mitogen-activated protein kinase(MAPK),and phosphatidylinositol 3-kinase/protein kinase B(PI3k/Akt),LIPUS promotes the prolifera-tion,migration,and osteogenic differentiation of osteogenic-related cells,thereby enhancing osseointegration of dental implants.Additionally,clinical studies have shown that bone mass increases around the implants after LIPUS treatment,with more pronounced growth observed on the buccal bone plate than on the palatal side.Furthermore,there is a lack of research that systematically summarizes the clinical evidence,in vitro and in vivo studies,and mechanisms of action re-garding the role of LIPUS in promoting osseointegration of implants.Therefore,the aim of this study is to discuss the mechanisms of effect of LIPUS on osseointegration of implants,with the goal of further enhancing the outcome of implant-supported prosthodontic treatment.关键词
低强度脉冲超声/牙种植体/骨结合/骨髓间充质干细胞/骨形成/骨质疏松症/降钙素基因相关肽/丝裂原活化蛋白激酶Key words
low-intensity pulsed ultrasound(LIPUS)/dental implants/osseointegration/bone marrow stromal stem cells/osteogenesis/osteoporosis/α-calcitonin gene-related peptide/mitogen-activated protein kinase分类
口腔医学引用本文复制引用
张昕宇,瞿方,胥春..低强度脉冲超声促进牙种植体骨结合的研究进展[J].口腔疾病防治,2025,33(5):417-424,8.基金项目
国家自然科学基金项目(82071157) （82071157）
上海交通大学医学院附属第九人民医院原创探索项目(JYYC002) This study was supported by the National Natural Science Foundation of China(No.82071157) （JYYC002）
Original Exploration Project of Shanghai Ninth People's Hospital,Shanghai JiaoTong University School of Medicine(No.JYYC002). （No.JYYC002）
