口腔疾病防治2025，Vol.33Issue(5)：425-432,8.DOI:10.12016/j.issn.2096-1456.202440265
锌指蛋白在口腔癌发生发展中的作用研究进展
Research progress on the role of zinc finger proteins in the development of oral cancer
摘要
Abstract
Oral cancer is one of the most common malignancies in the head and neck regions.few patients benefit from current clinical therapy.Zinc finger proteins(ZNFs)are one of the largest transcription factor family proteins in the human genome.ZNFs bind to DNA,RNA,and proteins through their unique three-dimensional structure created by zinc ions to regulate gene transcription,RNA packaging,and protein folding.In recent years,the number of studies focused on the functional mechanism of ZNFs in regulating the progression of oral cancer has been increasing,with focuses on:① ZNF677,ZNF460,ZNF154,ZNF132,ZNF281,Kaiso,and ZNF582,which regulate the invasion and metastasis of tumor cells;② ZNF750 and PEST-containing nuclear protein(PCNP),which regulate the cell cycle;③ ZNFs,which are involved in forming the tumor immune microenvironment,such as ZNF71 and myeloid zinc finger 1(MZF1).For example,methylation modification modulates the reduction of ZNF677 in oral cancer and reduces the proliferation,migration,and invasion of oral cancer cells by inhibiting the protein kinase B/forkhead box O3a(AKT/FOXO3a)path-way;and ZNF460 promotes the proliferation,migration,and invasion of oral cancer cells by regulating microRNA-320a/alpha thalassemia/mental retardation,X-linked(ATRX)axis.In addition,ZNF750 inhibits the growth and metastasis of oral cancer by suppressing cell cycle transcription factor activity.Further,ZNF71 promotes the progression of oral can-cer by reducing the infiltration of tumor immune cells.In this review,we will summarize the molecular mechanism,regu-latory meshwork,and pro-tumor and anti-tumor roles of ZNFs in the pathogenesis of oral cancer.Our study may provide a new strategy for the diagnosis and treatment of oral cancer.关键词
锌指蛋白/口腔癌/肿瘤细胞/肿瘤微环境/肿瘤免疫/肿瘤治疗Key words
zinc finger protein/oral cancer/tumor cells/tumor microenvironment/tumor immunity/tumor therapy分类
口腔医学引用本文复制引用
斯航,冯燕,余丽..锌指蛋白在口腔癌发生发展中的作用研究进展[J].口腔疾病防治,2025,33(5):425-432,8.基金项目
国家自然科学基金项目(82403404) （82403404）
四川省科学技术厅科技计划项目(2024JDRC0040) （2024JDRC0040）
四川省医学青年创新课题计划(Q23028) （Q23028）
国家卫生健康委核技术医学转化重点实验室开放课题(2023HYX028) This study was supported by the grants from National Natural Science Foundation of China(No.82403404) （2023HYX028）
Project of Science&Technology Department of Sichuan Province(No.2024JDRC0040) （No.2024JDRC0040）
Youth Innovation Project of Sichuan Pro-vincial Medical Association(No.Q23028) （No.Q23028）
NHC Key Laboratory of Nuclear Technology Medical Transformation(Mian-yang Central Hospital)(No.2023HYX028). （Mian-yang Central Hospital）
