感染、炎症、修复2025，Vol.26Issue(2)：76-82,7.DOI:10.3969/j.issn.1672-8521.2025.02.002
Ⅱ型肺泡上皮细胞在脓毒症急性肺损伤中的研究现状
Research progress of type II alveolar epithelial cells in acute lung injury caused by sepsis
摘要
Abstract
Sepsis-associated acute lung injury(SALI)is a common complication of sepsis,characterized by a high incidence and poor prognosis.However,the underlying pathophysiological mechanisms of SALI remain incompletely understood.Further exploration of the mechanisms driving SALI may facilitate targeted therapeutic strategies and improve patient outcomes.This article reviews the pathophysiological mechanism of type Ⅱ alveolar epithelial cells(AEC Ⅱ)in SALI and the potential clinical significance of type Ⅱ alveolar epithelial cells in SALI diagnosis and treatment,as well as the key problems in the study of type Ⅱ alveolar epithelial cells in SALI and the possible strategies to overcome these problems.The in-depth investigation of molecular mechanisms and pathophysiological characteristics in AEC Ⅱ not only elucidates the underlying pathogenesis of SALI,but also provides a scientific foundation for developing targeted therapeutic strategies.关键词
脓毒症急性肺损伤/Ⅱ型肺泡上皮细胞/肺泡-毛细血管屏障/肺泡表面活性物质/炎症反应Key words
Sepsis-associated induced acute lung injury/Type Ⅱ alveolar epithelial cells/Alveolar-capillary barrier/Pulmonary surfactant/Inflammatory response分类
临床医学引用本文复制引用
陈剑明,张敏,陶张斌,黎艳,苏霞镱,卢中秋..Ⅱ型肺泡上皮细胞在脓毒症急性肺损伤中的研究现状[J].感染、炎症、修复,2025,26(2):76-82,7.基金项目
国家自然科学基金项目(82272201) （82272201）
浙江省脓毒症诊疗中医药多学科交叉创新团队资助项目 （）
