国际妇产科学杂志2025，Vol.52Issue(2)：127-131,5.DOI:10.12280/gjfckx.20241066
高迁移率族蛋白A2在胎儿生长受限发病机制中的研究进展
Advances in the Pathogenesis of Fetal Growth Restriction by HMGA2
侯春艳 1杜秀萍 1王红红 1侯岳洋1
作者信息
- 1. 030000 太原,山西医科大学临床学科建设中心
- 折叠
摘要
Abstract
Fetal growth restriction(FGR)is one of the major pregnancy complications leading to stillbirth and adverse outcomes in newborns,with complex pathogenesis and limited clinical treatment.High-mobility group protein A2(HMGA2),a non-histone chromatin protein,plays a key role in embryonic development,angiogenesis and apoptosis regulation.Recent studies have shown that HMGA2 may be involved in the pathological process of FGR by regulating angiogenesis,endothelial cell function and multi-organ development-related signalling pathways.This article reviews the research progress of HMGA2 in the pathogenesis of FGR and explores its potential role in placental function,foetal hypoxia tolerance and organ development,with aim of providing a new theoretical basis and intervention strategy for the early prediction,diagnosis and targeted treatment of FGR.The in-depth study of the function of HMGA2 and its regulatory network will not only helps to reveal the molecular mechanism of FGR,but also lays an important foundation for the development of precision medicine therapeutic solutions in the future.关键词
胎儿生长迟缓/胎儿发育/HMGA2蛋白/信号传导/血管内皮生长因子类Key words
Fetal growth retardation/Fetal development/HMGA2 protein/Signal transduction/Vascular endothelial growth factors引用本文复制引用
侯春艳,杜秀萍,王红红,侯岳洋..高迁移率族蛋白A2在胎儿生长受限发病机制中的研究进展[J].国际妇产科学杂志,2025,52(2):127-131,5.
