国际妇产科学杂志2025，Vol.52Issue(2)：161-164,186,5.DOI:10.12280/gjfckx.20240867
妊娠合并重度凝血因子Ⅺ缺乏症二例
Two Cases of Severe Factor Ⅺ Deficiency in Pregnancy
赵鑫 1陈秀雯 1王雅楠 1王长智 1张夏兰1
作者信息
- 1. 515041 汕头大学医学院第二附属医院妇产科
- 折叠
摘要
Abstract
Factor Ⅺ deficiency is a rare autosomal inherited hemorrhagic disease with a prevalence of about one in a million.Heterozygous carriers often have no obvious bleeding tendency,and homozygous or compound heterozygous carriers often have severe factor Ⅺ deficiency.Factor Ⅺ deficiency in pregnancy is particularly rare and it has rarely been reported in China.Two cases of severe factor Ⅺ deficiency in pregnancy were reported,including one case of factor Ⅺ compound heterozygous mutation.Two patients were diagnosed with severe coagulation factor Ⅺ deficiency at the time of prenatal examination.After admission,a multidisciplinary consultation was conducted,evaluate 2 cases of patients without vaginal delivery contraindications,suggest by vaginal birth and anti-fibrinolytic drugs were used after labor.Healthy live infants were delivered vaginally under close monitoring.After delivery,tranexamic acid antifibrinolytic and strong uterine contraction agents were used to strengthen uterine contraction treatment.After delivery,both lower limbs were treated with air pressure to prevent thrombosis.After 4 days of hospitalization,the mother and child were discharged without complications.By reviewing the medical history clinical diagnosis and treatment process of the case and reviewing the relevant literature,the aim is to increase the clinicians understanding of the disease and accumulate more clinical diagnosis and treatment experience.关键词
凝固蛋白紊乱/因子Ⅺ/血液凝集障碍,遗传性/围产期管理/病例报告Key words
Coagulation protein disorders/Factor Ⅺ/Blood coagulation disorders,inherited/Perinatal management/Case reports引用本文复制引用
赵鑫,陈秀雯,王雅楠,王长智,张夏兰..妊娠合并重度凝血因子Ⅺ缺乏症二例[J].国际妇产科学杂志,2025,52(2):161-164,186,5.
