国际医药卫生导报2025，Vol.31Issue(7)：1179-1183,5.DOI:10.3760/cma.j.cn441417-20240924-07025
初治弥漫大B细胞淋巴瘤患者血清白细胞介素-6水平及其预后意义
Serum level of interleukin-6 and its prognostic significance in patients with newly diagnosed diffuse large B-cell lymphoma
摘要
Abstract
Objective To explore the serum level of interleukin-6(IL-6)in patients with newly diagnosed diffuse large B-cell lymphoma(ND-DLBCL)and its clinical significance.Methods A total of 66 patients with ND-DLBCL who were admitted to Fuzhou Second General Hospital and Fujian Medical University Union Hospital and 35 cases of healthy control individuals from Oct 2017 to Dec 2021 were selected for the retrospective analysis.Among the patients with ND-DLBCL,there were 39 males and 27 females with a median age of 59 years old.Among the healthy control individuals,there were 10 males and 25 females with a median age of 39 years old.The serum IL-6 levels were compared between the two groups.Of the 66 ND-DLBCL patients,4 were lost to follow-up and 62 were included for further analysis.The optimal cut-off value of serum IL-6 level to predict prognosis was obtained by the receiver operating characteristic curve.The patients were divided into a high level group(IL-6 ≥15.6 ng/L,39 cases)and a low level group(IL-6＜15.6 ng/L,23 cases)according to the cut-off value.The clinical and laboratory characteristics,3-year overall survival(OS)and progression-free survival(PFS)of the two groups were compared.x2 test and t test were used for statistical analysis.Results The serum level of IL-6 in the patients with ND-DLBCL[(35.95±33.66)ng/L]was higher than that in the healthy control individuals[(1.66±0.77)ng/L](t=6.012,P＜0.001).The optimal cut-off value of serum level of IL-6 for prognosis in patients with ND-DLBCL was 15.6 ng/L,and the area under curve was 0.705(0.558-0.852)(P＜0.05).Compared with the group with low level of serum IL-6,the proportions of the patients with presence of B symptoms[58.97％(23/39)vs.13.04％(3/23)]and high National Comprehensive Cancer Network-International Prognostic Index(NCCN-IPI)(≥4 points)[79.49％(31/39)vs.43.48％(10/23)]were higher in the high level group,but the OS rate of 3-year[71.79％(28/39)vs.100.00％(23/23)]and the PFS rate of 3-year[56.41％(22/39)vs.82.61％(19/23)]were lower in the high level group(all P＜0.05).Conclusions There was an abnormal elevation of serum IL-6 level in patients with ND-DLBCL.Meanwhile,high level of serum IL-6 was associated with poor prognosis in patients with ND-DLBCL.关键词
弥漫大B细胞淋巴瘤/白细胞介素-6/预后Key words
Diffuse large B cell lymphoma/Interleukin-6/Prognosis引用本文复制引用
张进萍,陈玲,黄震宇,王颖,黄晓玲,黄豪博..初治弥漫大B细胞淋巴瘤患者血清白细胞介素-6水平及其预后意义[J].国际医药卫生导报,2025,31(7):1179-1183,5.基金项目
福建省科技创新联合资金项目(2019Y9050) （2019Y9050）
福建省财政厅卫生健康专项(2021XH007) （2021XH007）
福建医科大学启航基金(2021QH1050) Joint Funds for the Innovation of Science and Technology,Fujian Province(2019Y9050) （2021QH1050）
Special Financial Funds of Fujian Province(2021XH007) （2021XH007）
Startup Fund for Scientific Research of Fujian Medical University(2021QH1050) （2021QH1050）
