中医学报2025，Vol.40Issue(5)：930-935,6.DOI:10.16368/j.issn.1674-8999.2025.05.149
中医药调控PI3K/AKT信号通路治疗少弱精子性不育症研究进展
Research Progress on TCM Regulating PI3K/AKT Signaling Pathway in Treatment of Oligoasthenospermia Infertility
摘要
Abstract
In recent years,the basic research of traditional Chinese medicine in the treatment of oligospermia has been widely carried out.As a key pathway regulating cell growth,proliferation and apoptosis,PI3K/AKT signaling pathway plays an important role in sper-matogenesis and maturation.Traditional Chinese medicine monomers such as dodder flavonoids and icariin,single Chinese medicines such as Huangjing(Rhizoma polygonati)and Xianmao(Rhizoma curculiginis),classic drug pairs such as Tusizi-Gouqizi(Semen Cuscutae-Lycium berry)and Niuxi-Wangbuliuxing(Achyranthes bidentata-Cowherb seed)as well as compound preparations such as Wuzi Yanzong Pill,Zuogui Pill and Yishen Qiangpi Formula,can promote the proliferation of spermatogenic cells,inhibit the apopto-sis of spermatogenic cells,and regulate oxidative stress to treat oligospermic infertility by regulating the pathway.There are still some limitations in the existing research,such as mainly focusing on basic experiments,lack of large-sample randomized controlled clinical trials,and the research on the treatment of this disease through PI3K/AKT signaling pathway by external treatment of traditional Chinese medicine is still blank,and future research should focus on carrying out standardized clinical research,exploring diversified treatment options,giving full play to the advantages of traditional Chinese medicine,and providing new ideas for the clinical treatment of oligoas-thenospermia infertility.关键词
少弱精子性不育症/中医药/PI3K/AKT信号通路/研究进展Key words
oligoasthenospermia infertility/Chinese medicine/PI3K/AKT signaling pathway/research progress分类
中医学引用本文复制引用
陈雪松,徐磊,姜子祥,史孟华,孙世钦,候中豪,秦国政..中医药调控PI3K/AKT信号通路治疗少弱精子性不育症研究进展[J].中医学报,2025,40(5):930-935,6.基金项目
国家自然科学基金项目(82060870,8237153698) （82060870,8237153698）
全国名老中医药专家传承工作室建设项目{中国中医药人教函[2022]75号} （）
云南省教育厅科学研究基金资助项目(2024Y381) （2024Y381）
