感染、炎症、修复2025，Vol.26Issue(2)：127-133,7.DOI:10.3969/j.issn.1672-8521.2025.02.012
TNF-α和TNFR与多信号衔接蛋白协同调控在乳腺癌中发挥的多效性生物学作用
The pleipotent biological effects of tumor necrosis factor alpha,tumor necrosis factor receptor and multi-signal adaptor proteins in synergistic regulation in breast cancer
摘要
Abstract
Breast cancer ranks first in the incidence rate of malignant tumors among women,posing a global public health issue.This article reviews the selective targeting effects of tumor necrosis factor alpha(TNF-α)and tumor necrosis factor receptor(TNFR)1 and TNFR2 in breast cancer and related therapeutic strategies,the expression and functions of TNFR1 and TNFR2 in different subtypes of breast cancer,as well as the dual biological effects and mechanisms of TNF-α induced apoptosis and anti-apoptosis.TNF-α and TNFR inhibit the phosphorylation of signal transducer and activator of transcription 5(STAT5)by interacting with multiple signal adaptor proteins,affect the function of breast cells,influence immune escape and drug resistance through the function of immune cells in the tumor microenvironment,resist TNF-α induced apoptosis,and induce tumor stemness and epithelial-mesenchymal transition of breast cancer.The complex signal transduction mechanism and the characteristic of playing different roles after binding to different receptors make TNF-α highly specific and complex in cellular signal transduction,suggesting that selective targeting of TNFR1 and TNFR2 may have more advantages than the traditional total TNF blocking therapy.关键词
乳腺癌/肿瘤坏死因子-α/肿瘤坏死因子-α受体/核因子-κB/肿瘤微环境/肿瘤干性/上皮-间质转化Key words
Breast cancer/Tumor necrosis factor alpha/Tumor necrosis factor receptor/Nuclear factor-κB/Tumor microenvironmen/Cancer stemness/Epithelial-mesenchymal transition/Signal transduction分类
医药卫生引用本文复制引用
徐厉程,符湛培,吴冶琴,王刚平..TNF-α和TNFR与多信号衔接蛋白协同调控在乳腺癌中发挥的多效性生物学作用[J].感染、炎症、修复,2025,26(2):127-133,7.基金项目
山东省自然科学基金资助项目(ZR2020MH319) （ZR2020MH319）
