国际医药卫生导报2025，Vol.31Issue(7)：1209-1211,3.DOI:10.3760/cma.j.cn441417-20240914-07031
苯磺酸氨氯地平致Alport综合征患儿重度牙龈增生1例
Amlodipine induced severe gingival hyperplasia in a child with Alport syndrome
摘要
Abstract
This article analyzed a boy with Alport syndrome who has been taking amlodipine besylate for a long time.The 15-year-old boy was diagnosed with Alport syndrome at 7 years and 7 months old(May 2016),and progressed to chronic kidney disease stage 5 at 10 years and 4 months old(February 2019).He started peritoneal dialysis in March 2019,and had been taking various antihypertensive drugs for many years due to the existence of malignant hypertension.However,his blood pressure was not well controlled,mostly in the 130-150/90-110 mmHg(1 mmHg=0.133 kPa)range.Gingival hyperplasia occurred in February 2023 and gradually worsened.CT examination,bone marrow cell blood examination,physical examination,and medication history were performed to diagnose the gingival hyperplasia associated with calcium channel blockers(CCB).Gingival hyperplasia improved significantly after amlodipine reduction.The exact mechanism of drug-induced gingival hyperplasia is not fully understood.Whether the severe gingival hyperplasia manifestation is related to the gene mutation causing collagen synthesis abnormality or increased drug susceptibility in the patient's underlying disease of Alport syndrome needs further research.关键词
苯磺酸氨氯地平/牙龈增生/儿童/Alport综合征Key words
Amlodipine besylate/Gingival hyperplasia/Children/Alport syndrome引用本文复制引用
刘玉洁,王向丽,赵公平,曹广海,张书锋,田明,刘翠华..苯磺酸氨氯地平致Alport综合征患儿重度牙龈增生1例[J].国际医药卫生导报,2025,31(7):1209-1211,3.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20230603) Henan Medical Science and Technology Joint Project(LHGJ20230603) （LHGJ20230603）
