广西科学院学报2025，Vol.41Issue(1)：45-57,13.DOI:10.13657/j.cnki.gxkxyxb.20250429.005
味觉SNP与环境因素对老年群体认知功能的影响
Effect of Taste-related SNPs and Environmental Factors on Cog-nitive Function in Elderly Populations
摘要
Abstract
The purpose of this study was to explore the effects of genetic factors and their interaction with en-vironmental factors on the cognitive function of the elderly in the Hongshui River Basin.A total of 895 elder-ly individuals from the Hongshui River Basin were included.A case-control design was used to divide them into cognitive normal group and cognitive impairment group for comparison.The Single Nucleotide Polymor-phism(SNP)loci related to taste perception were detected by extracting peripheral blood DNA,and the asso-ciation of each SNP locus with taste perception and cognitive status was evaluated.The Generalized Multi-fac-tor Dimensionality Reduction method(GMDR)was used to analyze the effects of SNP-SNP and SNP-envi-ronment interaction on cognitive status.The results showed that multiple SNP loci were significantly correla-ted with the taste function of the elderly.The mutant allele C of the bitter taste receptor gene TAS2R38 rs10246939 locus was a risk factor for cognitive function in the dominant genetic model,individuals with the T/C and C/C genotypes have a higher risk of disease than ones with the T/T genotype,while the C/A geno-type of CLEC5A rs1285950 locus was higher in the cognitive impairment group than the A/A genotype.The C/A genotype might be a risk factor for cognitive impairment.GMDR analysis showed that the four-locus model of AGK,DENND11 and CLEC5A genes and the SNP-environment interaction model including taste function and gender all had good predictive effects on cognitive function.In summary,the cognitive function of the elderly populations in the Hongshui River Basin is affected by multi-gene genetic factors,and taste-re-lated SNP loci and their interactions with environmental factors such as taste function and gender play a sig-nificant role in it.关键词
味觉功能/认知功能/GMDR/味觉相关SNP位点/健康长寿Key words
taste function/cognitive function/GMDR/taste-related SNPs/healthy longevity分类
基础医学引用本文复制引用
胡帅军,陈宁园,黄玲,覃源,彭均华,潘尚领..味觉SNP与环境因素对老年群体认知功能的影响[J].广西科学院学报,2025,41(1):45-57,13.基金项目
国家自然科学基金项目(32060188,81860205,82360286)资助. （32060188,81860205,82360286）
