广西科学院学报2025，Vol.41Issue(1)：58-71,14.DOI:10.13657/j.cnki.gxkxyxb.20250429.006
嗅觉相关SNP及环境因素对长寿人群认知功能的影响
Effects of the Interaction Between Olfaction-associated Single Nucleotide Polymorphism and Environmental Factors on the Cognitive Impairment in Long-lived Population
摘要
Abstract
To explore the effects of seven olfactory-related Single Nucleotide Polymorphism(SNP)on OR7D4,OR7E24,OR9Q1 and SNCA genes and their interaction with environmental factors on the cognitive function of long-lived population in Hongshui River Basin,the improved Multiplex Ligation Detection Reac-tion(iMLDR)method was used to genotype the SNP of the long-lived group(283 cases),the offspring group(296 cases),the local group(326 cases)and the Hezhou group(286 cases)in the Hongshui River Ba-sin in this study.Firstly,chi-square test and unconditional logistic regression were used to analyze the fre-quency distribution of SNP genotypes and their alleles in the four groups and their correlation with Cognitive Impairment(CI).Then,linkage disequilibrium analysis was performed to construct haplotypes for investi-gating the underlying interactions among genetic loci.Finally,the Generalized Multi-factor Dimensionality Reduction analysis(GMDR)was used to further analyze the effect of gene-environment interaction on CI in long-lived population.The results showed that:there were significant differences in the frequency distribu-tion of OR9Q1 rs2245676,OR7D4 rs61729907 genotypes and its alleles between the long-lived group and the Hezhou group(P<0.05).In the long-lived group,the risk of CI in individuals carrying the OR7E24 rs2240927 T allele was significantly lower than that of the C allele(P<0.05).In the long-lived group and local group,OR7E24 haplotype T-C would increase the risk of CI;in the local group,OR7E24 haplotype C-T and the children group OR9Q1 haplotype G-T would reduce the risk of CI.OR7D4 haplotype G-C would in-crease the risk of CI in the long-lived group and local group(P<0.05).There were SNP-SNP interactions a-mong OR7E24 rs2240927,OR7E24 rs12608694 and SNCA rs894278 in the long-lived population.There was a SNP-environment interaction between OR7D4 rs61729907,olfactory and Waist-to-hip Ratio(WHR).There was a haplotype-environment interaction between OR7D4 G-C,olfaction,triglyceride,and high-density lipo-protein cholesterol(P<0.05).In summary,there are significant differences in the polymorphisms of olfac-tory-related genes between the long-lived population in the Hongshui River Basin and the non-local popula-tion.The interaction between some SNPs and the interaction between gene and the environment have a cer-tain effect on the cognitive aging of the long-lived population.关键词
嗅觉/单核苷酸多态性/认知障碍/基因-环境交互作用/长寿Key words
olfaction/single nucleotide polymorphism/cognitive impairment/gene-environment interaction/long-lived分类
基础医学引用本文复制引用
侯鹏,李佳,彭均华..嗅觉相关SNP及环境因素对长寿人群认知功能的影响[J].广西科学院学报,2025,41(1):58-71,14.基金项目
国家自然科学基金项目(32060188)资助. （32060188）
