纺织工程学报2025，Vol.3Issue(2)：54-64,11.
多巴胺改性丝胶蛋白粘合剂的制备及性能
Preparation and properties of dopamine-modified sericin adhesive
摘要
Abstract
Developing adhesives with strong underwater adhesion and antibacterial properties is a significant challenge.Sericin molecular chains were modified for wet adhesion via dopamine(DA)oxidative self-polymer-ization,and the modified protein chains were cross-linked with tannic acid(TA)to prepare a TA-DA/Ser adhe-sive.Test results indicated that the adhesive exhibited viscoelastic solid behavior at the macroscopic level,pro-viding good mechanical strength.The successful modification of silk fibroin in solution was confirmed,and hy-drogen bonding was identified as the primary driving force for the cross-linking between tannic acid and the modified sericin.The adhesive demonstrated a maximum adhesion strength of 86.22 kPa on pigskin tissue,a DPPH radical scavenging rate of up to 91.62%,and survival rates of only 1.07%and 1.03%for Escherichia coli and Staphylococcus aureus,respectively.Cytotoxicity and wound healing experiments showed that the adhesive met the Grade II cytotoxicity standard and promoted wound healing in SD rats.The TA-DA/Ser adhesive holds potential applications in suture-free wound closure and tissue adhesion.关键词
多巴胺/丝胶蛋白/单宁酸/水下粘合剂/抗菌性能Key words
dopamine/sericin/tannic acid/underwater adhesive/antimicrobial properties分类
生物科学引用本文复制引用
李奕潇,李智鹏,吴子微,王昊宇,卢神州,邢铁玲..多巴胺改性丝胶蛋白粘合剂的制备及性能[J].纺织工程学报,2025,3(2):54-64,11.基金项目
国家自然科学基金资助项目(51973144) （51973144）
江苏高等学校优势学科建设项目(PAPD). （PAPD）
