吉林中医药2025，Vol.45Issue(4)：479-483,5.DOI:10.13463/j.cnki.jlzyy.2025.04.024
指压法通过SIRT1调节肥胖模型大鼠炎症的作用机制研究
Mechanisms of finger-pressing massage on regulating inflammation in obesity model rats
摘要
Abstract
Objective To observe the effects of finger-pressing massage on the expression levels of TNF-α and IL-6 in the serum,as well as the expression level of SIRT1 in adipose tissue,of obesity model rats,and to explore its mechanisms on regulating inflammation in these rats.Methods Wistar rats were randomly assigned to a blank group,a model group,a drug group,and a treatment group.The blank group received no intervention,while the rats in the other three groups were fed with a high-sugar,high-fat diet for 8 weeks to establish an obesity model.After that,the treatment group underwent a finger-pressing massage intervention,while the drug group was given resveratrol by gavage,and the model group received an equivalent volume of 0.9%sodium chloride solution.These interventions lasted for 4 weeks.After treatment,ELISA was used to measure the concentrations of TNF-αand IL-6 in the rats'serum,while RT-qPCR was used to detect the mRNA expression of SIRT1 in their adipose tissue.Results Compared to the blank group,significant differences were observed in the body mass change,Lee's indexes,serum levels of TNF-α and IL-6,as well as the mRNA expression of SIRT1 in adipose tissue among the model,drug,and treatment groups(P<0.05).When compared to the model group,the rats in the treatment group exhibited a slower increase in body mass(P<0.05),a decrease in Lee's indexes(P<0.05),reduced serum levels of TNF-α and IL-6(P<0.05),and a significant increase in the mRNA expression level of SIRT1 in adipose tissue(P<0.05).Conclusion Finger-pressing massage exhibits a substantial impact on improving the inflammatory state in obesity model rats,which is potentially linked to its regulatory effect on TNF-α,IL-6,and SIRT1.关键词
指压法/肥胖模型大鼠/炎症/沉默信息调节因子1Key words
finger-pressing massage/obesity model rats/inflammation/silence information regulator 1(SIRT1)分类
医药卫生引用本文复制引用
周新峰,刘明军,谭怡,王潇,杨龙,陈邵涛..指压法通过SIRT1调节肥胖模型大鼠炎症的作用机制研究[J].吉林中医药,2025,45(4):479-483,5.基金项目
国家自然科学基金项目(82174525) （82174525）
吉林省科技发展计划项目(YDZJ202201ZYTS195) （YDZJ202201ZYTS195）
长春中医药大学青年优秀学科骨干培养项目(202305) （202305）
