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In vivo consequences of varying degrees of OTOA alteration elucidated using knock-in mouse models and pseudogene contamination-free long-read sequencing

Ju Ang Kim Sungjin Park Bong Jik Kim Chung Lee Go Hun Seo Hane Lee Jin Hee Han Ava Niazi Joosang Park Byung Yoon Choi

基因与疾病（英文）2025，Vol.12Issue(3)：88-92,5.

基因与疾病（英文）2025，Vol.12Issue(3)：88-92,5.DOI:10.1016/j.gendis.2025.101533

In vivo consequences of varying degrees of OTOA alteration elucidated using knock-in mouse models and pseudogene contamination-free long-read sequencing

Ju Ang Kim ¹Sungjin Park ²Bong Jik Kim ³Chung Lee ⁴Go Hun Seo ⁵Hane Lee ⁵Jin Hee Han ⁶Ava Niazi ²Joosang Park ²Byung Yoon Choi⁷

作者信息

1. Department of Neurobiology,University of Utah,Salt Lake City,UT 84112,USA||Department of Otorhinolaryngology-Head and Neck Surgery,Seoul National University Bundang Hospital,Seoul National University College of Medicine,Seongnam 13620,South Korea
2. Department of Neurobiology,University of Utah,Salt Lake City,UT 84112,USA
3. Department of Otorhinolaryngology,Chungnam National University College of Medicine,Chungnam National University Sejong Hospital,Sejong 30099,South Korea||Brain Research Institute,Chungnam National University College of Medicine,Daejeon 35015,South Korea
4. Department of Pathology,Severance Hospital,Yonsei University College of Medicine,Seoul 03722,South Korea
5. billion,Inc.,Seoul 06193,South Korea
6. Brain Research Institute,Chungnam National University College of Medicine,Daejeon 35015,South Korea||Department of Otorhinolaryngology-Head and Neck Surgery,Seoul National University Bundang Hospital,Seoul National University College of Medicine,Seongnam 13620,South Korea
7. Department of Otorhinolaryngology-Head and Neck Surgery,Seoul National University Bundang Hospital,Seoul National University College of Medicine,Seongnam 13620,South Korea
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摘要

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Ju Ang Kim,Sungjin Park,Bong Jik Kim,Chung Lee,Go Hun Seo,Hane Lee,Jin Hee Han,Ava Niazi,Joosang Park,Byung Yoon Choi..In vivo consequences of varying degrees of OTOA alteration elucidated using knock-in mouse models and pseudogene contamination-free long-read sequencing[J].基因与疾病（英文）,2025,12(3):88-92,5.

基金项目

This work was supported by the National Research Founda-tion of Korea(NRF)grant funded by the Korean government(MSIT)(No.2021R1C1C1007980 to B.J.K.),Chungnam Na-tional University Sejong Hospital Research Fund,2022,and Chungnam National University(to B.J.K.).This study was supported by the Basic Science Research Program through the NRF,funded by the Ministry of Education(No.2021R1A2C2092038 to B.Y.C.),Bio Core Facility Center pro-gram(No.NRF-2022M3A9G1014007 to B.Y.C.),the Basic Research Laboratory program through the NRF,funded by the Ministry of Education(No.RS-2023-0021971031482092640001 to B.Y.C.),and the Technology Innovation Program(No.K_G012002572001 to B.Y.C.)funded By the Ministry of Trade,Industry & Energy(MOTIE,Korea).This study is also funded by SNUBH(Seoul National University Bundang Hospital)intramural research fund(No.13-2022-0010,02-2017-0060,16-2023-0002,13-2023-0002,16-2022-0005,13-2024-0004,and 13-2017-0013 to B.Y.C.).This work was supported by the National Institute on Deafness and Other Communication Disorders(NIDCD),part of the US National Institutes of Health(No.R01DC018814 to S.P.). （NRF）

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