华南农业大学学报2025，Vol.46Issue(3)：336-341,6.DOI:10.7671/j.issn.1001-411X.202407006
肝脏RNA-seq揭示杜洛克猪剩余采食量的社会遗传效应调控的关键基因和分子途径
Liver RNA-seq reveals key genes and molecular pathways regulating the social genetic effects of residual feed intake in Duroc pigs
摘要
Abstract
[Objective]This study aims to elucidate the molecular regulatory mechanisms of the social genetic effects of residual feed intake(SGE-RFI)in Duroc pigs,and reveal the biological basis of how it influences group behavior through energy metabolism pathways,thereby providing a theoretical basis for improving feed utilization efficiency in pigs.[Method]By employing RNA sequencing technology,a comprehensive transcriptome analysis of the liver tissue in Duroc pigs was conducted,systematically screening for key differentially expressed genes related to the SGE-RFI trait.Functional enrichment methods were used to analyze the biological pathways involved.[Result]The study identified 360 significantly differentially expressed genes.Functional analysis indicated that these genes were primarily enriched in energy-related pathways such as mitochondrial oxidative phosphorylation and ATP metabolism,suggesting an indirect influence on social behavior through the regulation of energy homeostasis.The coordinated expression changes in the apolipoprotein gene cluster APOA1,APOC3 and APOA4 revealed the interaction between the neuroendocrine system and lipid metabolism during the social genetic effect regulation.[Conclusion]This research has constructed a multi-dimensional regulatory network for SGE-RFI in Duroc pigs,offering not only a new perspective for understanding the genetic mechanisms of group behavior,but also laying a molecular foundation for the precise selection of breeding pigs with low residual feed intake and the optimization of group feeding management strategies.关键词
剩余采食量/社会遗传效应/杜洛克猪/肝脏/RNA-seqKey words
Residual feed intake/Social genetic effect/Duroc Pig/Liver/RNA seq分类
农业科技引用本文复制引用
崔晟頔,陈佳苗,王翔枫,吴平先,唐国庆,王书杰,赵真坚,陈栋,申琦,余杨,王俊戈,陈子旸,禹世欣..肝脏RNA-seq揭示杜洛克猪剩余采食量的社会遗传效应调控的关键基因和分子途径[J].华南农业大学学报,2025,46(3):336-341,6.基金项目
国家生猪技术创新中心先导科技项目(NCTIP-XD/B01) （NCTIP-XD/B01）
四川省科技厅项目(2020YFN0024,2021ZDZX0008,2021YFYZ0030) （2020YFN0024,2021ZDZX0008,2021YFYZ0030）
