菌物研究2025，Vol.23Issue(2)：79-92,14.DOI:10.13341/j.jfr.2024.1835
植物内生真菌生产紫杉醇:挑战与机遇
Paclitaxel Production by Plant Endophytic Fungi:Challenges and Opportunities
摘要
Abstract
Since isolated from Taxus sp.in 1971,paclitaxel,a natural anticancer substance,has become one of important drugs in the treatment of many types of cancers including breast and ovarian cancers.However,the scarcity and slow growth of its source plant greatly limit the supply capacity of paclitaxel.Over the years,more than 200 species of endophytic fungi have been reported to produce paclitaxel,indicating therefore that the use of endophytic fungi for production of paclitaxel could be the most promising way to solve the above situations.Even so,the synthetic pathway of paclitaxel in endophytic fungi is still unknown,remaining a problematic issue for the scientific community.This review focuses on the classification,distribution and production of paclitaxel-producing plant endophytic fungi together with discussions on the evolutionary origin and putative mechanism of paclitaxel synthesis by endophytic fungi,the current methods for improvement of fungal paclitaxel production as well as and the challenges and opportunities faced by current researches.Through extensive understanding of the mechanism of paclitaxel synthesis in endophytic fungi and use of the advanced novel biotechnological tools,the application of endophytic fungi in paclitaxel production will be more promising in future.关键词
紫杉醇/植物内生真菌/生物合成/产量Key words
paclitaxel/endophytic fungi in plants/synthetic mechanism/yield分类
生物学引用本文复制引用
吴佳雯,张盛权,尹文兵..植物内生真菌生产紫杉醇:挑战与机遇[J].菌物研究,2025,23(2):79-92,14.基金项目
国家自然科学基金面上项目(32170066),中国科学院基础前沿科学研究计划从0到1原始创新项目(ZDBS-LY-SM016),中国科学院战略生物资源衍生库项目(KFJ-BRP-009-005),中国科学院基础与交叉前沿科研先导专项B(XDB0830000) （32170066）
