菌物研究2025，Vol.23Issue(2)：141-150,10.DOI:10.13341/j.jfr.2024.1711
韧革菌素类化合物结构特征、生物活性及生物合成研究进展
Research Advances of Structure,Biological Activity and Biosynthesis of Vibralactone Derivatives
摘要
Abstract
Vibralactone is a natural product isolated from a fungus of the species Stereaceae to have a β-fused bicyclic lactone backbone structure.This compound is known to have a good inhibitory activity against the pancreatic lipase,indicating its potential value for development of a newtype obesity drug.It has attracted extensive attention from experts and scholars around the world because of its unique structural features and good biological activity.This paper summarizes the advances of research on the chemical structure and synthesis,biological activity and biosynthesis of vibralactone and its analogues as well.Basing on the current results and research foundation,we also carry out discussions together with future prospects in the development and application as well as potential technological breakthroughs of vibralactone biosynthesis in this review,which should provide available references for the drug exploration,chemical synthesis and biosynthesis of this substance and its derivatives.关键词
韧革菌素/β-内酯双环/生物合成Key words
vibralactone/bicyclic β-lactone/biosynthesis分类
生物学引用本文复制引用
闫新元,张璇,段应策,刘成伟..韧革菌素类化合物结构特征、生物活性及生物合成研究进展[J].菌物研究,2025,23(2):141-150,10.基金项目
中央高校基本科研业务专项资金项目(2572023AW40),泰山学者专家计划项目(tsqn2021030130) （2572023AW40）
