临床肝胆病杂志2025，Vol.41Issue(4)：736-741,6.DOI:10.12449/JCH250420
慢性乙型肝炎患者低病毒血症临床治疗的挑战与策略
Challenges and strategies for clinical treatment of low-level viremia in chronic hepatitis B patients
摘要
Abstract
Hepatitis B virus(HBV)infection is a global public health issue,affecting the health of 250 million people worldwide.Despite the significant progress in antiviral therapy for HBV,some patients still experience low-level viremia(LLV)after receiving antiviral therapy and fail to achieve viral clearance,with an HBV DNA load remaining at a relatively low level of 20-2 000 IU/mL.LLV is often caused by multiple factors such as the high stability of the virus,the difficulty in clearing the virus with antiviral drugs,host immune factors,and drug resistance,which increase the difficulties in antiviral therapy.In addition,LLV can also cause liver damage,which may eventually progress to severe outcomes such as hepatocellular carcinoma.This article reviews LLV in hepatitis B in terms of diagnosis,influencing factors,clinical significance,and treatment strategies.关键词
乙型肝炎,慢性/低病毒血症/病毒载量/抗病毒药Key words
Hepatitis B,chronic/Low-Level Viremia/Viral Load/Antiviral Agents引用本文复制引用
甘惠琳,石翠翠,李光明..慢性乙型肝炎患者低病毒血症临床治疗的挑战与策略[J].临床肝胆病杂志,2025,41(4):736-741,6.基金项目
国家自然科学基金资助项目(82170617) （82170617）
上海交通大学医学院消化科学院2023年信谊消化病研究基金(KY-2023-04-02) National Natural Science Foundation of China(82170617) （KY-2023-04-02）
2023 Xinyi Digestive Disease Research Fund from the School of Gastroenterology,School of Medicine,Shanghai Jiao Tong University(KY-2023-04-02) （KY-2023-04-02）
